Acquired Syphlis by Non Sexual Contact

Syphilis Infection Clinical Trial

Official title:

Descriptive Cohort of Acquired Syphlis by Non Sexual Contact

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04455425
• Other study ID #: Si non sexual
• Status: Completed
• Start date: July 15, 2020
• Est. completion date: May 15, 2021

Study information

• Verified date: February 2023
• Source: Hospital de Niños R. Gutierrez de Buenos Aires
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Syphilis is classically described as a sexually transmitted disease. As this source of contagious has been described long ago -mainly though by observation- when children presents with acquired syphilis, child abuse is always considered and must be ruled out by specialists in a careful evaluation.

However, muco-cutaneous lesions can be a contagious source for congenital syphilis; therefore the possibility of non-sexual transmission through intimate contact with infected people through humid lesions (such as in kisses, breastfeeding, food-handling) or contaminated fomites (towels, bed sheets, underwear, cups, pacifiers, cutlery) could be considered. Experts worldwide have observed this non-sexual transmission, as described in many reports in literature.

The investigators will study retrospectively patients from a cohort with non-sexual transmission. The diagnosis criteria used for acquired syphilis were as follows: age under 18 years with treponemic and nontreponemic positive tests, secondary-syphilis suspicious lesions and negative maternal syphilis serology. Nonsexual contagious was defined as contacts without physical and psychosocial indicators of sexual abuse according to current guides. In this cohort, in every case a psychosocial evaluation was completed with a written report in order to evaluate sexual contact probability.

The teamo will describe these patients clinical and laboratory findings, family and close acquaintances serologies and probable source of contagious.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: May 15, 2021
• Est. primary completion date: April 15, 2021
• Gender: All
• Age group: 0 Years to 18 Years

Eligibility

INCLUSION CRITERIA:

• Children with treponemic and non-treponemic positive tests with primary or secondary-syphilis suspicious lesions

EXCLUSION CRITERIA:

• Children with diagnose criteria positive for Congenital syphilis

Related Conditions & MeSH terms

• Syphilis
• Syphilis Acquired
• Syphilis Infection

Locations

Country	Name	City	State
Argentina	Hospital de Niños Ricardo Gutierrez	Buenos Aires	Capital Federal

Sponsors (1)

Lead Sponsor	Collaborator
Hospital de Niños R. Gutierrez de Buenos Aires

Country where clinical trial is conducted

Argentina, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Describe diagnose process of a cohort of children with assumed non-sexual acquired syphilis	Describe the interdisciplinary approach of patients with acquired syphilis and how non-sexual transmission was assumed	Past 20 years
Primary	Describe serology titers from patients with non - sexually acquired syphilis and from their close contacts	Investigators will report serology titers from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening	Past 20 years
Primary	Describe reported symptoms and physical findings at diagnose and during follow-up f children with assumed non-sexual acquired syphilis and their close contacts	Investigators will describe symptoms and physical findings from patients with non - sexually acquired syphilis at diagnose and follow-up until cure, and from their close contacts at diagnose and during follow up of those resulting positive at contact screening	Past 20 years