Synovial Chondrosarcoma: a Single Institution Experience

Synovial Chondrosarcoma Clinical Trial

Official title:

Synovial Chondrosarcoma: a Single Institution Experience

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03776942
• Other study ID #: SynoChondroS
• Status: Completed
• Start date: August 7, 2018
• Est. completion date: August 31, 2019

Study information

• Verified date: December 2018
• Source: Istituto Ortopedico Rizzoli
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

single institution cases series review of histological, radiological and clinical data

Description:

single institution cases series review of histological, radiological and clinical data. Investigators will retrieve from the archives of the Rizzoli institute all the cases with a histological diagnosis of synovial chondrosarcoma.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 9
• Est. completion date: August 31, 2019
• Est. primary completion date: December 1, 2018
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Male and female patients treated at Rizzoli Institute from 01 January 1982 to 31 December 2017

• Diagnosis of synovial chondrosarcoma

• Age = 18 years

• Histological slides / formalin-fixed paraffin-embedded tissue tumor (FFPE) blocks from archive available to perform the histology analysis

• Written informed consent prior to any study-specific analysis and/or data collection

Exclusion Criteria:

• Patients with histological diagnosis different from synovial chondrosarcoma

Related Conditions & MeSH terms

• Chondrosarcoma
• Synovial Chondrosarcoma

Locations

Country	Name	City	State
Italy	IRCC Rizzoli Orthopedic Institute	Bologna

Sponsors (1)

Lead Sponsor	Collaborator
Istituto Ortopedico Rizzoli

Country where clinical trial is conducted

Italy, 

References & Publications (5)

Bertoni F, Unni KK, Beabout JW, Sim FH. Chondrosarcomas of the synovium. Cancer. 1991 Jan 1;67(1):155-62. — View Citation

Biazzo A, Confalonieri N. Synovial chondrosarcoma. Ann Transl Med. 2016 Aug;4(15):280. doi: 10.21037/atm.2016.06.23. — View Citation

Campanacci DA, Matera D, Franchi A, Capanna R. Synovial chondrosarcoma of the hip: report of two cases and literature review. Chir Organi Mov. 2008 Dec;92(3):139-44. doi: 10.1007/s12306-008-0062-3. Epub 2008 Dec 4. Review. — View Citation

Ng VY, Louie P, Punt S, Conrad EU. Malignant Transformation of Synovial Chondromatosis: A Systematic Review. Open Orthop J. 2017 May 31;11:517-524. doi: 10.2174/1874325001711010517. eCollection 2017. — View Citation

Zamora EE, Mansor A, Vanel D, Errani C, Mercuri M, Picci P, Alberghini M. Synovial chondrosarcoma: report of two cases and literature review. Eur J Radiol. 2009 Oct;72(1):38-43. doi: 10.1016/j.ejrad.2009.05.029. Epub 2009 Jun 11. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	selection and review of cases of Synovial Chondrosarcoma	IDH1 and IDH2 analysis will be performed in order to better understand tumor characteristics and to identify the best therapeutic approach.	baseline (Day0)