Clinical Trials Logo

Sympathetic; Imbalance clinical trials

View clinical trials related to Sympathetic; Imbalance.

Filter by:
  • None
  • Page 1

NCT ID: NCT05515640 Active, not recruiting - Clinical trials for Traumatic Brain Injury

Dysautonomia and Systemic Interactions in Traumatic Brain Injury

DYSI-TBI
Start date: August 1, 2019
Phase:
Study type: Observational

Following brain injury, complex interactions between the nervous system and other organs are frequently encountered. Systemic effects may be induced by dysregulation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. This observational study will investigate the link between clinical, physiological and biochemical expressions of dysautonomic reactions and physiological stress, and their relations to sympathetic activation in traumatic brain injury patients treated in the neurointensive care unit.

NCT ID: NCT04271241 Completed - Vasodilation Clinical Trials

Vascular Function Improvements After Chronic Passive Stretching

Start date: January 7, 2019
Phase: N/A
Study type: Interventional

Acutely, during different bouts of passive stretching (PS), blood flow (Q ̇) and shear rate ( ) in the feeding artery of the stretched muscles increases during the first two elongations and then it reduces during the following bouts. This hyperemic response during the first two elongations is mediated by the local release of vasoactive molecules (e.g. nitric oxide, NO). This phenomenon disappears during the following elongations due to the NO and other vasoactive molecule depletion. The relaxation phase between stretching bouts, instead, is always characterized by hyperemia as results of stretch-induced peripheral resistances decrease. Whether chronic PS administration may influence vascular function is still a matter of investigation. The hypothesis is that repetitive PS-induced Q ̇ and changes may be an enough stimulus to provoke increments in NO bioavailability, thus improving vasomotor response.