Sweating Clinical Trial
Official title:
Alternative Haemodiafiltration in Summer Season for Chronic Kidney Disease Patients
Verified date | May 2023 |
Source | Assiut University |
Contact | manar salah |
Phone | 01092058750 |
manarsalah303[@]gmail.com | |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Hemodiafiltration is a renal replacement technique combining diffusion and convection to enhance solute removal. Post dialyser replacement fluid is administered to achieve the target fluid balance. The skin is the largest human organ playing an important role in thermal and Na regulation and skin blood flow is 8.5-10%of cardiac output .
Status | Not yet recruiting |
Enrollment | 100 |
Est. completion date | June 21, 2025 |
Est. primary completion date | June 21, 2024 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 60 Years |
Eligibility | Inclusion Criteria: chronic kidney disease group: 1. stage 3,4 2. Age(18-60)yrs old. 3. Not on dialysis. 4. Without uremic symptoms nor standard indication for dialysis Exclusion Criteria: 1. History of cerebrovascular accidents. 2. History of advanced cardiac disease (heart failure, recent acute coronary syndrome, and cardiac arrhythmia). 3. Active skin lesion 4. volume overload. 5- advanced liver cirrhosis, respiratory failure, and malignancy. |
Country | Name | City | State |
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n/a |
Lead Sponsor | Collaborator |
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Assiut University |
al-Tamer YY, Hadi EA, al-Badrani II. Sweat urea, uric acid and creatinine concentrations in uraemic patients. Urol Res. 1997;25(5):337-40. doi: 10.1007/BF01294662. — View Citation
Baker LB. Physiology of sweat gland function: The roles of sweating and sweat composition in human health. Temperature (Austin). 2019 Jul 17;6(3):211-259. doi: 10.1080/23328940.2019.1632145. eCollection 2019. — View Citation
Blank IH, Moloney J 3rd, Emslie AG, Simon I, Apt C. The diffusion of water across the stratum corneum as a function of its water content. J Invest Dermatol. 1984 Feb;82(2):188-94. doi: 10.1111/1523-1747.ep12259835. — View Citation
Huang CT, Chen ML, Huang LL, Mao IF. Uric acid and urea in human sweat. Chin J Physiol. 2002 Sep 30;45(3):109-15. — View Citation
Joo CH, Allan R, Drust B, Close GL, Jeong TS, Bartlett JD, Mawhinney C, Louhelainen J, Morton JP, Gregson W. Passive and post-exercise cold-water immersion augments PGC-1alpha and VEGF expression in human skeletal muscle. Eur J Appl Physiol. 2016 Dec;116(11-12):2315-2326. doi: 10.1007/s00421-016-3480-1. Epub 2016 Oct 3. — View Citation
Ronco C. Hemodiafiltration: Technical and Clinical Issues. Blood Purif. 2015;40 Suppl 1:2-11. doi: 10.1159/000437403. Epub 2015 Sep 8. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | assessment of improvement of kidney function test( urea and creatinine) | kidney function test (serum urea and creatinine im mg\dl) will measured before the procedure with weekly follow up | 1 year | |
Primary | assess improvement of blood pressure | follow up blood pressure (systolic and diastolic blood pressure in mm hg) | 1 year | |
Secondary | assessment of improvement in serum potassium level | measure potassium level in mmol\L with weekly follow up | 1 year |
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