Swallowing Clinical Trial
Official title:
Corticobulbar Motor Output in Aging Adults
The goal of this project is to examine the area of the brain that controls muscle movement for a group of muscles important for swallowing, and to see how that area changes over 2 weeks of time.
A large number of our nation's veterans develop dysphagia due to the myriad of potential
etiological sources of swallowing disorders, including stroke and head and neck cancer. The
Veteran's Health Administration has recently identified dysphagia as a major clinical focus
for the VA system (Sullivan & Dennis, 2006). In order to accurately assess adaptations in
motor cortex, it is first necessary to have a reliable tool for measuring organizational
representation in the motor cortex. Transcranial magnetic stimulation (TMS) is a desirable
choice for such measurement because of the ability to identify causative relationships
between an area of motor cortex stimulated and muscle response. Therefore, the specific
research objectives of this proposal are:
1. To demonstrate the reproducibility of TMS mapping of the submental muscle group in
healthy older adults between 60 and 80 years of age
2. To determine the neural representation of submental musculature in the motor cortex of
healthy older adults between 60 and 80 years of age.
Twenty healthy adults, 10 men and 10 women, between the ages of 60 and 80 years will serve
as research participants. TMS will be used to establish motor maps of the submental muscles.
Subjects will undergo two testing sessions, on day 1 and day 14. The results from each
session will be compared to assess excitability and representation within the motor cortex,
and to assess stability and reliability of measurement.
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Observational Model: Cohort, Time Perspective: Prospective
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