Surgical Wound Dehiscence Clinical Trial
Official title:
Prevention of Fascial Dehiscence With Prophylactic Onlay Mesh in Emergency Laparotomies: a Randomized Clinical Trial
Facial dehiscence elicit high morbidity and mortality. This complication may arise in more than 8.5% of high-risk patients. Addressing risk factors and optimizing surgical technique are guarded as mainstay measures for prevention, but their efficacy is questionable. The aim of this study is to analyze the influence of using a polypropylene onlay prophylactic mesh on the incidence of fascial dehiscence in emergency surgery and associated complications.
Fascial dehiscence is associated with high morbidity and mortality rates. It occurs in more than 8.5% of high-risk patients. Current preventive measures described are control of risk factors and optimization of surgical technique. Despite that, the incidence of such complication remained stable in the last decades, highlighting the low efficacy of such measures. Polypropilene onlay mesh has been used to avoid incisional hernias in selected elective patients, and could be useful in the prevention of fascial dehiscence. In emergency situations, especially in contaminated and infected surgical procedures, safety and efficacy of mesh is controversial. In this study the investigators aimed to evaluate the influence of polypropilene prophylactic onlay mesh on the incidence of fascial dehiscence in high-risk patients undergoing midline emergency laparotomy. As secondary outcome, the associated morbidity, including surgical site occurence, will be analyzed. The study design will be a randomized controlled trial. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT00654641 -
Prevention of Wound Complications After Cesarean Delivery in Obese Women Utilizing Negative Pressure Wound Therapy
|
N/A | |
| Recruiting |
NCT04920253 -
Real World Evidence With the Debritom+ TM Novel Micro Water Jet Technology at a Single Wound Center
|
N/A | |
| Terminated |
NCT01679678 -
A Study, Performed in Subjects With Post Traumatic-post Surgical ,Venus Insufficiency and Diabetic Hard to Heal/Chronic Wounds, to Evaluate the Safety and Efficacy of PolyHeal-2 Versus PolyHeal in Once Daily Regimen
|
Phase 2 | |
| Completed |
NCT01050673 -
Trial of Versajet Compared With Conventional Treatment in Acute and Chronic Wounds
|
N/A | |
| Terminated |
NCT01083472 -
Repair of Challenging Abdominal Wall Defects: Strattice(TM) TM in Abdominal Wall Repair (StAR)
|
Phase 4 | |
| Terminated |
NCT00260494 -
Acupuncture and Post-Surgical Wound Healing
|
N/A | |
| Active, not recruiting |
NCT04257097 -
Reinforced PTFE Meshes Versus Customized Titanium Meshes
|
N/A | |
| Not yet recruiting |
NCT04894604 -
A Safety and Performance PMCF Investigation of the Avance® Solo NPWT System in Surgically Closed Incisions
|
N/A | |
| Completed |
NCT01658163 -
Use of 2-octyl-cyanoacrylate Together With a Self-adhering Mesh
|
N/A | |
| Completed |
NCT05716490 -
Optimizing Closed Incision Negative Pressure Wound Therapy in Emergency Laparotomy
|
N/A | |
| Enrolling by invitation |
NCT02581904 -
Prevena Vascular Groin Wound Study
|
Phase 4 | |
| Recruiting |
NCT02467998 -
Negative Pressure Wound Therapy Registry
|
||
| Recruiting |
NCT02280733 -
A Real World, Observational Registry of Chronic Wounds and Ulcers
|
||
| Recruiting |
NCT02322554 -
Cellular and Tissue Based Therapy Registry
|
||
| Completed |
NCT02453165 -
Vaginal Cuff Dehiscence Following Total Laparoscopic Hysterectomy: Laparoscopic vs. Transvaginal Cuff Closure
|
N/A | |
| Completed |
NCT04286334 -
Three-dimensional Bone Regeneration Using Custom-made Meshes With and Without Collagen Membrane
|
N/A | |
| Completed |
NCT02879487 -
Vaginal Cuff Dehiscence at Total Laparoscopic Hysterectomy
|
N/A | |
| Completed |
NCT02565043 -
The Clinical Efficacy of RENASYS TOUCH NPWT System in the Management of Acute, Sub-acute and Chronic Wounds
|
N/A | |
| Terminated |
NCT01693484 -
Application of Indocyanine Green Angiography for Closed Operative Calcaneus Fractures
|
Phase 2/Phase 3 |