Clinical Trials Logo
  1. Home
  2. Surgical Site Infections
  3. NCT03685604

PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site — PICASSo  

Surgical Site Infections Clinical Trial

Official title:
Polyvinylpyrrolidone (PVP) Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site: a Cluster-randomized Multicenter Trial

Clinical Trial Summary

Prospective cluster-randomized multicenter cross-over trial to prove non-inferiority of PI compared to CHX in preoperative skin antisepsis

Clinical Trial Description

Surgical site infections (SSIs) are the most common nosocomial infections in surgical patients causing significant increases in morbidity, mortality, and health care costs. As they are usually caused by components of the normal skin flora, disinfection of the surgical site with an antiseptic skin preparation is standard practice prior to any surgical intervention. The most commonly used disinfectants are either chlorhexidine in alcoholic solution (CHX) or PVP iodine in alcoholic solution (PI) This prospective cluster-randomized multicenter cross-over trial is to prove non-inferiority of PI compared to CHX in preoperative skin antisepsis in abdominal and cardiothoracic surgery in regard of SSIs. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03685604
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact
Status Completed
Phase Phase 4
Start date September 10, 2018
Completion date June 30, 2020
View Details
See also
  Status Clinical Trial Phase
Completed NCT04969302 - Examination of the Effect of Skin Antisepsis With Pre-heated Povidone Iodine on Surgical Site Infections: A Quasi-Experimental Study N/A
Completed NCT02253069 - PHMB-based Antiseptic Use in Full-thickness Surgical Wounds N/A
Completed NCT01472549 - The Skin Prep Study N/A
Not yet recruiting NCT02503904 - Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection Phase 2/Phase 3
Completed NCT01888367 - Safety, Efficacy and Tolerability Study of up to 20 mL of DFA-02 in Patients Undergoing Abdominal Surgery Phase 2
Completed NCT02619773 - Effect of Mupirocin Dressings Versus Island Dressings on Surgical Site Infections in Elective Colorectal Surgery N/A
Completed NCT01425697 - Eliminate Risk of Cardiac Surgical Site Events N/A
Terminated NCT02799667 - Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery N/A
Recruiting NCT02436395 - Povidone-iodine and the Normal Saline Cleaning the Incision for the SSIs N/A
Active, not recruiting NCT03402945 - Prevention of Infections in Cardiac Surgery (PICS) Prevena Study Phase 4
Withdrawn NCT02666365 - Continuous v Bolus Infusion of Cefazolin During Ventral Hernia Repair Phase 4
Completed NCT01971138 - Review of Surgical Site Infection Registration Routine at Surgery Departments in Sweden and Validation of One of the Used Routines N/A
Completed NCT01949935 - Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting Phase 3
Completed NCT01138852 - Ampicillin/Sulbactam Versus Cefuroxime as Antimicrobial Prophylaxis for Cesarean Section Phase 4
Recruiting NCT06378359 - Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
Not yet recruiting NCT02012517 - Antibiotic Prophylaxis in Prosthetic Breast Reconstructions Phase 4
Completed NCT03686553 - St. Barbara Specialised Regional Hospital No. 5: Surveillance of Healthcare-Associated Infections
Completed NCT01916733 - A Quality Initiative to Improve Glycemic Control in Diabetic and Non-Diabetic Insulin Study N/A
Not yet recruiting NCT06043414 - Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT N/A
Completed NCT05090657 - Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures Phase 2