Surgical Site Infections Clinical Trial
Official title:
Ampicillin / Sulbactam Versus Cefuroxime as Antimicrobial Prophylaxis for Cesarean Section: a Randomized Study
The efficacy and safety of a single dose of ampicillin/sulbactam compared to a single dose of
cefuroxime at cord clamp for prevention of postcesarean infectious morbidity has not been
assessed.
Women scheduled for cesarean delivery were randomized to receive a single dose of either 3g
of ampicillin-sulbactam or 1.5g of cefuroxime intravenously, after umbilical cord clamping.
An evaluation for development of postoperative infections and risk factor analysis was
performed.
The efficacy and safety of a single dose of ampicillin/sulbactam compared to a single dose of
cefuroxime at cord clamp for prevention of postcesarean infectious morbidity has not been
assessed.
The investigation was designed to evaluate the efficacy and safety of a single dose of
ampicillin/sulbactam 3g compared to a single dose of cefuroxime 1.5g in preventing
postoperative morbidity. The primary outcome was development of an infection either at the
surgical site or elsewhere e.g. urinary tract infection.
A prospective randomized controlled study was performed from July 2004 to December 2008 in
one major tertiary care hospital in Athens Greece. All patients undergoing a cesarean
delivery were eligible.Patients were randomly assigned to receive either 1.5g of cefuroxime,
or 3g of ampicillin/ sulbactam intravenously after the time the umbilical cord was clamped.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04969302 -
Examination of the Effect of Skin Antisepsis With Pre-heated Povidone Iodine on Surgical Site Infections: A Quasi-Experimental Study
|
N/A | |
| Completed |
NCT02253069 -
PHMB-based Antiseptic Use in Full-thickness Surgical Wounds
|
N/A | |
| Completed |
NCT01472549 -
The Skin Prep Study
|
N/A | |
| Completed |
NCT03685604 -
PVP Iodine vs Chlorhexidine in Alcohol for Disinfection of the Surgical Site
|
Phase 4 | |
| Not yet recruiting |
NCT02503904 -
Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection
|
Phase 2/Phase 3 | |
| Completed |
NCT01888367 -
Safety, Efficacy and Tolerability Study of up to 20 mL of DFA-02 in Patients Undergoing Abdominal Surgery
|
Phase 2 | |
| Completed |
NCT02619773 -
Effect of Mupirocin Dressings Versus Island Dressings on Surgical Site Infections in Elective Colorectal Surgery
|
N/A | |
| Completed |
NCT01425697 -
Eliminate Risk of Cardiac Surgical Site Events
|
N/A | |
| Terminated |
NCT02799667 -
Do Single Use Negative Pressure Dressings Reduce Wound Complications in Obese Women After Cesarean Delivery
|
N/A | |
| Recruiting |
NCT02436395 -
Povidone-iodine and the Normal Saline Cleaning the Incision for the SSIs
|
N/A | |
| Active, not recruiting |
NCT03402945 -
Prevention of Infections in Cardiac Surgery (PICS) Prevena Study
|
Phase 4 | |
| Withdrawn |
NCT02666365 -
Continuous v Bolus Infusion of Cefazolin During Ventral Hernia Repair
|
Phase 4 | |
| Completed |
NCT01971138 -
Review of Surgical Site Infection Registration Routine at Surgery Departments in Sweden and Validation of One of the Used Routines
|
N/A | |
| Completed |
NCT01949935 -
Efficacy Study of Mupirocin on Infection After Coronary Artery Bypass Grafting
|
Phase 3 | |
| Recruiting |
NCT06378359 -
Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients
|
||
| Not yet recruiting |
NCT02012517 -
Antibiotic Prophylaxis in Prosthetic Breast Reconstructions
|
Phase 4 | |
| Completed |
NCT01916733 -
A Quality Initiative to Improve Glycemic Control in Diabetic and Non-Diabetic Insulin Study
|
N/A | |
| Completed |
NCT03686553 -
St. Barbara Specialised Regional Hospital No. 5: Surveillance of Healthcare-Associated Infections
|
||
| Not yet recruiting |
NCT06043414 -
Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
|
N/A | |
| Completed |
NCT05090657 -
Nasal Photodisinfection in All Patients Presenting for Surgery for a Wide Range of Surgical Procedures
|
Phase 2 |