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Clinical Trial Summary

The aim of the study is to evaluate the gut microbiome (i.e. bacteria, viruses, and fungi that reside in the gut) of people undergoing abdominal surgery, evaluate whether specific diets can change the gut microbiome, and, if so, whether those changes translate into better surgical outcomes.


Clinical Trial Description

Standard of care: patients undergoing major abdominal colorectal surgery are sometimes advised to eat healthfully prior to surgery, but without more specific recommendations regarding their diet. Research Activities: 1. Screening: eligible patients will be identified through screening the clinic schedules. 2. Enrollment: in person or remotely, after the patient is determined to require major abdominal surgery, they will be invited to participate in the study. If they consent to participate, they will be randomized to receive either low-fat/high-fiber diet, high-fermented diet, or continue with their normal diet for 10 days prior to the surgery. 3. Intervention: at baseline, data will be collected regarding clinical information of the patients (age, body mass index, comorbidities, medications or supplements, physical activity levels, antibiotic or probiotic use in the past six months), and baseline dietary pattern, which will be evaluated through application of a validated Food Frequency Questionnaire. Patients in the intervention arms (low- fat/high-fiber diet or high-fermented diet) will receive all their meals for the 10 days preceding surgery. Patients in the control arm will receive a $25 grocery voucher Adherence to the diet will be checked daily through a digital application (SmartIntake®), which collects and analyzes data through the Remote Food Photography Method. Stool samples will be collected in five moments: at the beginning of the study, after the 10-day dietary intervention, during surgery, upon the first bowel movement after surgery, and between 21-30 days after surgery. The stool samples will be sent for analysis of the microbiome. A fragment of the resected bowel will also be sent for analysis of the microbiome. 4. Closeout: After surgery, all patients will receive the same standard dietary protocol and care, and will be followed for 30 days without any further intervention. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05027763
Study type Interventional
Source Stanford University
Contact
Status Not yet recruiting
Phase N/A
Start date September 2021
Completion date June 2022

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