24 Vs 48 Hours of Cefazolin or Cefuroxime as Prophylaxis

Status Completed

Clinical Trial Summary

A randomized control trial studying the effect of prophylactic antibiotics to reduce surgical site infections following cardiac surgery in adults using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin (Cefuroxime).

Clinical Trial Description

A prospective randomized controlled patient blinded study with 2x2 factional design. It aims to study optimal duration of antibiotic to reduce surgical site infections following cardiac surgery in adults 24 or 48 hours using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin (Cefuroxime). Patients shall remain on either medicines for 24 or 48 hours. The primary endpoints of the study are:(1) 48 hours antibiotic prophylaxis is superior to 24 hours in adult cardiac surgery (2) Cefuroxime is superior to Cafazolin as a prophylactic antibiotic in adult cardiac surgery. Secondary endpoints include; organisms causing surgical site infections, length of hospital and ICU stay, and worsening in renal function. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04303390
Study type	Interventional
Source	Saud Al Babtain Cardiac Center
Contact
Status	Completed
Phase	Phase 4
Start date	February 6, 2018
Completion date	May 31, 2022

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