Surgery in Early Childhood Clinical Trial
Official title:
Surgery in Early Life and Child Development at School-entry: A Population-based Study
The central hypothesis is that surgery and anesthesia exposure in children with immature
structural and functional brain development has long-term adverse effects on child
development at school-entry compared with children not exposed to anesthesia.
The secondary hypothesis is that frequency of surgery and anesthesia exposure in children
with immature structural and functional brain development has a dose-dependent association
with worsened child development outcomes at school-entry.
The overall objective is to investigate the association between surgery/anesthesia
exposure(s) in children in Ontario and major child development outcomes (physical health and
well being, social competence, emotional maturity, and language and cognitive development)
at school entry as measured by the Early Development Instrument.
n/a
Observational Model: Cohort, Time Perspective: Retrospective