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Surfactant Dysfunction clinical trials

View clinical trials related to Surfactant Dysfunction.

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NCT ID: NCT06090981 Recruiting - Clinical trials for Meconium Aspiration Syndrome

Early Bolus Surfactant Replacement Therapy Versus Standard Care in Term Neonates With Meconium Aspiration Syndrome

Start date: March 12, 2022
Phase: N/A
Study type: Interventional

The objective of the study is to compare the total duration of respiratory support in term neonates (≥37weeks) with meconium aspiration syndrome, who are provided early(≤2hr) bolus surfactant therapy versus standard care.

NCT ID: NCT05002478 Recruiting - Infant Clinical Trials

Infants With Severe Acute Respiratory Distress Syndrome: The Prone Trial

Start date: July 30, 2022
Phase: N/A
Study type: Interventional

The main objective is to determine the short-term effect of prone positioning in infants with infection-associated severe acute respiratory distress syndrome. The investigators compare oxygenation parameters and measurements from electrical impedance tomography (EIT) and lung ultrasonography (LUS) in mechanically ventilated infants in prone position versus supine position after surfactant administration.

NCT ID: NCT04777760 Recruiting - Clinical trials for Acute Respiratory Distress Syndrome

Surfactant for Neonatal Respiratory Distress Syndrome(NRDS) and Neonatal Acute Respiratory Distress Syndrome(NARDS)

Start date: January 1, 2021
Phase:
Study type: Observational

In preterm infants with neonatal respiratory distress syndrome (NRDS), exogenous pulmonary surfactant(PS) replacement therapy is one of the most important therapeutic breakthrough to reduce neonatal mortality. Nowadays, PS is commonly used in newborn infants with respiratory distress, but the incidences of bronchopulmonary dysplasia(BPD) and/or death are inconsistent. The result indicates that not all preterm infants with respiratory distress can be beneficial from PS. In 2017, the international neonatal ARDS (NARDS) collaborative group provides the first consensus definition for NARDS. And whether or not PS being beneficial for preterm infants with NARDS remains unknown.

NCT ID: NCT03822780 Recruiting - Clinical trials for Surfactant Dysfunction

Hydroxychloroquin (HCQ) in chILD of Genetic Defect

Start date: July 1, 2017
Phase: N/A
Study type: Interventional

The purpose of this proposed research is to investigate the efficacy and safety of hydroxychloroquine sulfate (HCQ, Quensyl) for pediatric ILD(chILD) caused by pulmonary surfactant-associated genes mutations.