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Supratentorial PNETs clinical trials

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NCT ID: NCT00749723 Completed - Ependymomas Clinical Trials

Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children

HIT-REZ-2005
Start date: February 1, 2006
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to improve overall survival while maintaining a good quality of life in pediatric patients with refractory or recurrent brain tumors (medulloblastomas, supratentorial PNETs, ependymomas WHO grade II and III). Response to different chemotherapy options (intravenous versus oral chemotherapy, intraventricular chemotherapy) as part of a multimodal therapy will be assessed. Progression-free, overall survival and toxicity will be evaluated additionally.