Supratentorial Neoplasms Clinical Trial
Official title:
Effect of Remifentanil Infusion Alone During the Closure Period for Early Emergence and Hemodynamic Stability in Patients Undergoing Supratentorial Craniotomy
Total intravenous anaesthesia using propofol and remifentanil are routinely used drugs for
this purpose. The hemodynamic stability and at the same time early emergency are the main
goals following neurosurgery. However there is no standard for discontinuation time for
manually controlled systems today.
The investigators aimed to study the effect of remifentanil infusion alone for early
emergence and hemodynamic stability during the closure period in patients undergoing
supratentorial craniotomy.
Adult, American society of Anaesthesiologist score I-II, 80 patients who underwent elective supratentorial craniotomy for tumour resection were randomly assigned to group I or II. In group I; propofol was discontinued during the dural closure. After the propofol was discontinued, remifentanil dose was increased with the guidance of bispectral index spectrum and hemodynamic parameters. In group II; propofol discontinued before the end of the surgery. Time to awakening and extubation time, adverse events, total remifentanil and propofol consumptions and side effects were recorded. Heart rate and blood pressure were recorded during this period. ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT04607525 -
Dexmedetomidine Infusion Effect on Hemodynamic Variables During Craniotomy
|
Phase 4 | |
Not yet recruiting |
NCT02929147 -
Comparison of Efficacy and Safety of the Postoperative Analgesia Methods
|
Phase 4 | |
Completed |
NCT00389883 -
Anaesthesia for Supratentorial Tumor Resection
|
Phase 3 | |
Completed |
NCT00972790 -
Scalp Nerve Blocks for Post-Craniotomy Pain
|
N/A | |
Completed |
NCT00179803 -
Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors
|
Phase 2 | |
Recruiting |
NCT04316208 -
Effect of PEEP on Subdural Pressure, Optic Nerve Sheath Diameter, Lung Compliance and Brain Perfusion Pressure
|
N/A | |
Recruiting |
NCT02168075 -
Mannitol Brain Relaxation Effect
|
N/A | |
Completed |
NCT04941040 -
Opioid Free VS Opioid Anesthesia for Craniotomies
|
Phase 1 | |
Recruiting |
NCT02113358 -
Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial
|
N/A | |
Not yet recruiting |
NCT04344132 -
Pre- vs. Postoperative Scalp Block for Pain Control After Supratentorial Craniotomy
|
N/A |