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Mannitol Brain Relaxation Effect — MANNITOL  

Supratentorial Neoplasms Clinical Trial

Official title:
Can Mannitol Increments Provide More Brain Relaxation in Patients Undergoing Craniotomy for Supratentorial Brain Tumor Removal?

Clinical Trial Summary

Mannitol is widely used in patients with elevated intracranial pressure. In neurosurgical field, especially in large size or with brain edema, it is necessary to decrease brain volume to facilitate surgical approach. In general, 0.25 -1.5g of mannitol per kilogram has been known to decrease ICP effectively. But there are some debates in regard to appropriate dose of mannitol.

Clinical Trial Description

Previous meta-analysis reported that mannitol has dose-response relationship with intracranial pressure. Another study of Sorani showed dose-response relationship between mannitol and intracranial pressure (ICP) in traumatic brain injury patients.

In this study, authors would investigate that mannitol increments can provide more brain relaxation in patients undergoing craniotomy for supratentorial brain tumor removal. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Outcomes Assessor), Primary Purpose: Supportive Care

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02168075
Study type Interventional
Source Seoul National University Hospital
Contact Hee Pyung Park, MD PhD
Phone 82-2-2072-2466
Email hppark@snu.ac.kr
Status Recruiting
Phase N/A
Start date June 2014
View Details
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Completed NCT04941040 - Opioid Free VS Opioid Anesthesia for Craniotomies Phase 1
Completed NCT02593942 - Remifentanil Infusion Alone During the Closure Period for Early Emergence Following Craniotomy Phase 4
Recruiting NCT02113358 - Comparison of Stroke Volume Variation-guided Normovolemic and Restrictive Fluid Management During Craniotomy: a Randomized Controlled Trial N/A
Not yet recruiting NCT04344132 - Pre- vs. Postoperative Scalp Block for Pain Control After Supratentorial Craniotomy N/A