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Supratentorial Neoplasms clinical trials

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NCT ID: NCT04941040 Completed - Clinical trials for Supratentorial Neoplasms

Opioid Free VS Opioid Anesthesia for Craniotomies

Start date: July 5, 2021
Phase: Phase 1
Study type: Interventional

Hemodynamic control during craniotomies can be a bit hectic specially during periods of intense noxious stimulation. For long anesthesiologists used high doses of opioids such as fentanyl and remifentanyl to provide analgesia with a good hemodynamic control during intraoperative period in patients undergoing craniotomies. However, the use of opioids was not devoid of side effects. Exploring other anesthetic plans using multiple opioid free anesthetic adjuvants that have analgesic effects given together in small doses appear to be appealing plan. This idea is the basis of our proposed study in which we compare the hemodynamic effects of using opioid free anesthesia versus opioid anesthesia in cranial surgeries.

NCT ID: NCT04691128 Completed - Clinical trials for Supratentorial Tumor

Desflurane and Brain Relaxation in Craniotomy

Start date: January 26, 2021
Phase: N/A
Study type: Interventional

Optional brain relaxation improves the surgeon's operating conditions and is likely to minimize the degree of retraction injury ,with the potential for providing patients with a better outcome. The choice of anesthetic drugs can affect intraoperative brain relaxation. Propofol suppresses brain metabolism, reduces cerebral blood flow, and provides satisfactory brain relaxation. Desflurane is often criticized in neurosurgery due to its cerebral vasodilation and potential to increase intracranial pressure, however, it has been found to have a little clinical significance. This study intends to compare the effects of desflurane with propofol on brain relaxation in patients with supratentorial tumors under mild hyperventilation, and to provide new clinical evidence for the use of desflurane in neurosurgical anesthesia.

NCT ID: NCT04607525 Completed - Clinical trials for Hemodynamic Instability

Dexmedetomidine Infusion Effect on Hemodynamic Variables During Craniotomy

Start date: November 21, 2020
Phase: Phase 4
Study type: Interventional

There is no clear consensus among neuroanesthesiologists regarding which anesthetic regimen is optimal for craniotomy. Propofol and short-acting opioids (such as remifentanil, fentanyl, or sufentanil) are commonly used. However, use of opioids is associated with increased risk of respiratory depression and postoperative nausea and vomiting. Dexmedetomidine is a highly selective α2-adrenoreceptor agonist that has been considered as a useful and safe adjunct to anesthesia for various surgical procedures

NCT ID: NCT04094974 Completed - Clinical trials for Supratentorial Brain Tumors

Heartrate Variability and Intraoperative Brain Conditions in Supratentorial Tumors

Start date: October 12, 2019
Phase:
Study type: Observational

This study aims to determine the relationship between heart rate variability and intraoperative brain relaxation conditions in patients with brain tumors.

NCT ID: NCT03570203 Completed - Clinical trials for Supratentorial Brain Tumor

Spectrum of Serum Sodium Disturbances in Patients With Non-sellar/Suprasellar Supratentorial Tumors

Start date: December 15, 2013
Phase:
Study type: Observational

This study was designed to quantify the incidence of hyponatremia in patients of supratentorial/supra-sellar lesions and observe their effect on neurological morbidity and mortality.

NCT ID: NCT03444519 Completed - Clinical trials for Supratentorial Tumors

The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours

Start date: March 1, 2018
Phase: N/A
Study type: Interventional

Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration. This study aimed to compare the effects of the mannitol in different use times, on the brain relaxation, electrolyte, lactate levels of the blood, peroperative fluid balance and the volume of the urine in supratentorial mass resection surgeries.

NCT ID: NCT03406403 Completed - Clinical trials for LMA Versus Mgso4 in Attenuating Stress Response During Emergence of Supratentorial Tumours Patients

A Comparative Study Between Laryngeal Mask Airway and Magensium Sulphate in Attenuating Systemic Stress Response During Emergence of Patients Undergoing Supratentorial Tumours.

Start date: January 19, 2018
Phase: N/A
Study type: Interventional

To evaluate the efficacy of replacement of ETT with LMA and administration of Magnesium sulphate at the end of the surgery in attenuating systemic stress response during emergence of patients undergoing supratentorial tumours

NCT ID: NCT03033693 Completed - Clinical trials for Anesthesia, Brain Tumor, Supratentorial,Outcome

Study of the Depth of Anesthesia on Postoperative Clinical Outcome in Patients With Supratentorial Tumor

DEPTH
Start date: February 1, 2017
Phase: N/A
Study type: Interventional

Recent studies have shown that deep anesthesia is associated with poor outcome. There is still lack of randomized controlled trials with large sample size on the effect of depth of anesthesia on the postoperative outcomes in patients undergoing brain tumor resection. The investigators are performing a randomized and parallel group trial. The aim of the study is to determine whether there is a causal relationship between the depth of anesthesia and postoperative clinical outcome in patients undergoing supratentorial tumor surgery.

NCT ID: NCT02593942 Completed - Clinical trials for Supratentorial Neoplasms

Remifentanil Infusion Alone During the Closure Period for Early Emergence Following Craniotomy

Start date: January 2015
Phase: Phase 4
Study type: Interventional

Total intravenous anaesthesia using propofol and remifentanil are routinely used drugs for this purpose. The hemodynamic stability and at the same time early emergency are the main goals following neurosurgery. However there is no standard for discontinuation time for manually controlled systems today. The investigators aimed to study the effect of remifentanil infusion alone for early emergence and hemodynamic stability during the closure period in patients undergoing supratentorial craniotomy.

NCT ID: NCT02457845 Completed - Glioblastoma Clinical Trials

HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors

Start date: May 2016
Phase: Phase 1
Study type: Interventional

This study is a clinical trial to determine the safety of injecting G207 (a new experimental virus therapy) into a recurrent or progressive brain tumor. The safety of combining G207 with a single low dose of radiation, designed to enhance virus replication and tumor cell killing, will also be tested.