Supratentorial Brain Tumor Clinical Trial
Official title:
The Effect of Intravenous Single Dose of Magnesium Sulphate on Attenuation of Hemodynamic Pressor Response After Myfield's Clamp Application During Craniotomies
Use of Mayfield skull clamp during craniotomies; results in a sharp and intense noxious stimulus which results in a severe hemodynamic pressor response. Many strategies have been reported to blunt this undesirable pressor effect. This prospective, double blind, and randomized study is the first to evaluate the effect of MgSo4 on attenuation of hemodynamic pressor activity after head clamp application during craniotomies.
Background: Use of Mayfield skull clamp during craniotomies; results in a sharp and intense
noxious stimulus which results in a severe hemodynamic pressor response. Many strategies have
been reported to blunt this undesirable pressor effect. This prospective, double blind, and
randomized study is the first to evaluate the effect of MgSo4 on attenuation of hemodynamic
pressor activity after head clamp application during craniotomies.
Methods: This randomized, double blind, and prospective study was done in Neurosurgical
department at ElSahel Teaching Hospital in Cairo from February 2016 till august 2017. All
adult patients aged from 18 to 60 years of both genders, ASA physical status I and II
scheduled for craniotomies were assessed to enter this study. Seventy one patients were
assessed preoperatively, sixty of them were enrolled and assigned in two groups (n=30 each).
Group M received 50 mg/kg MgSo4 in 100 ml 0.9 sodium Chloride 15 minutes prior to anesthesia
induction over 15 minutes. Group S received 100ml 0.9% Sodium Chloride over the same period
with the same rate.Mean HR was recorded as a primary outcome , meanwhile; MAP and the need
for a bolus dose of fentanyl was considered a secondary outcome.
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