Acute Sodium Bicarbonate Supplementation in Athletes

Supplementation Clinical Trial

Official title:

The Effect of Acute Sodium Bicarbonate Supplementation on Buffering Potential Kinetics, Physical Capacity and Discipline-Specific Performance

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03810404
• Other study ID #: ULS00006
• Status: Active, not recruiting
• Phase: Phase 3
• Start date: December 20, 2018
• Est. completion date: January 20, 2025

Study information

• Verified date: May 2024
• Source: Poznan University of Physical Education
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to verify the effect of acute sodium bicarbonate (SB) and placebo (PLA) supplementation on buffering potential kinetics, physical capacity, discipline-specific performance as well as concentration of diagnostically significant blood biochemical indices in athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Description:

Effective muscle work is conditioned by maintaining the proper range of muscles pH, regulated by buffering systems, in which the main role is played by bicarbonates (HCO3-). For this reason, sodium bicarbonate (SB) is often proposed as an ergogenic agent, especially during high-intensity efforts. Until now the major limitation to SB supplementation has been the gastrointestinal (GI) side effects. There is also a lack of data of the individual SB-induced changes of buffering potential kinetics and its actual connection with physical capacity and discipline-specific performance. Therefore, this study aims to examine the effect of acute, different-dose SB ingestion on buffering potential kinetics, physical capacity, discipline-specific performance as well as changes of diagnostically significant blood biochemical indices concentration in athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 50
• Est. completion date: January 20, 2025
• Est. primary completion date: November 1, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• written consent to participate,

• a current medical clearance to practice sports,

• training experience: at least 2 years,

• minimum of 4 workout sessions (in the discipline covered by the study) a week.

Exclusion Criteria:

• current injury,

• any health-related contraindication,

• declared general feeling of being unwell,

• unwilling to follow the study protocol.

Related Conditions & MeSH terms

• Sport
• Supplementation

Intervention

Dietary Supplement:
• Sodium bicarbonate supplementation
Interventions: The experimental procedure for each athlete included an acute SB supplementation in a different-dose regimen in order to assess whether the dose affects the actual physical and exercise capacity (doses: 0.15-, 0.25-, 0.35- and 0.50 g/kgFFM (0.12-, 0.20-, 0.28- and 0.40 g/kgBM), respectively). SB (Alkala, SANUM, Poland) will be administered as dissolved form in a 750 ml of fluid (water + fruit juice). On testing days the SB will be taken before physical and exercise capacity tests session. Between the SB and PLA or a PLA and SB treatments, a minimum 7-day washout period will be introduced.
• Placebo treatment
Interventions: The experimental procedure for each athlete will be included an PLA supplementation. Placebo will be administered in a form of 750 ml of fluid (water + fruit juice). On testing days the PLA will be taken before physical and exercise capacity tests session. Between the PLA and SB or a SB and PLA treatments, a minimum 7-day washout period will be introduced.

Locations

Country	Name	City	State
Poland	Department of Sports Dietetics, Poznan University of Physical Education	Poznan

Sponsors (1)

Lead Sponsor	Collaborator
Poznan University of Physical Education

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in anaerobic capacity after sodium bicarbonate supplementation and placebo treatment	The Wingate cycling test carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Primary	Changes in discipline-specific exercise capacity after sodium bicarbonate supplementation and placebo treatment	The discipline-specific exercise capacity tests carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Primary	Changes of bicarbonate concentration in blood after sodium bicarbonate supplementation and placebo treatment	Bicarbonate (HCO3-) [mmol/L] concentration analysis in blood carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Primary	Changes of base excess concentration in blood after sodium bicarbonate supplementation and placebo treatment	Base excess [mmol/L] concentration analysis in blood carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes of pH in blood after sodium bicarbonate supplementation and placebo treatment	Blood pH (pH units) analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes of lactate concentration in blood after sodium bicarbonate supplementation and placebo treatment	Lactate [mmol/L] concentration analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes of pyruvate concentration in blood after sodium bicarbonate supplementation and placebo treatment	Pyruvate [mmol/L] concentration analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes in blood glucose concentration after sodium bicarbonate supplementation and placebo treatment	Glucose [g/dl] concentration analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes in hemoglobin concentration after sodium bicarbonate supplementation and placebo treatment	Hemoglobin (Hb) [g/dl] concentration analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes of blood cells concentration in blood after sodium bicarbonate supplementation and placebo treatment	Blood cells [mln/mm³] concentration analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes of creatine kinase activity in blood after sodium bicarbonate supplementation and placebo treatment	Creatine kinase [U/L] activity analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation
Secondary	Changes of lactate dehydrogenase activity in blood after sodium bicarbonate supplementation and placebo treatment	Lactate dehydrogenase [U/L] activity analysis carried out at baseline, and after SB and PLA supplementation	Baseline and during 1 day of acute SB and PLA supplementation