Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer

Superficial Bladder Cancer Clinical Trial

Official title:

Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00322699
• Other study ID #: WBPDT-577-04
• Status: Completed
• Phase: Phase 1/Phase 2
• First received: May 4, 2006
• Last updated: October 25, 2012
• Start date: February 2005
• Est. completion date: March 2011

Study information

• Verified date: August 2011
• Source: North Florida/South Georgia Veterans Health System
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Food and Drug AdministrationUnited States: Federal Government
• Study type: Interventional

Clinical Trial Summary

This protocol is evaluating efficacy and toxicity of three sequential whole bladder photodynamic treatment with Photofrin and red laser light (630 nm) in the management of superficial bladder cancer (non-muscle invasive) in those patients who have failed or are not candidates for conventional intravesical therapy.

Description:

Patient Evaluation and Treatment:

1. Patients will sign an IRB-approved informed consent form

2. Initial patient assessments will include:

• eligibility

• History and physical.

• clinical profile

• upper urinary tract imaging (if clinically indicated)

• urinary symptoms assessment

WBPDT Treatment:

1. Porfimer Sodium (Photofrin) 1.5 mg/kg iv followed 2 days later by whole bladder laser light at 630 nm with target light doses of 1200 Joules (+/-100Joules)

2. Patients will undergo three sequential WBPDT treatments

3. Treatments will occur at least three months apart

4. All WBPDT treatments will occur within 12 months

Decisions to administer a second or third WBPDT will be based upon urological and medical assessment of the individual patient and not necessarily dependent upon Dose Limiting Toxicities (DLT) or early stopping endpoints (although such information may be taken into account in the individual patient assessment). Patients experiencing DLT may continue WBPDT at the investigator's discretion at the same or reduced doses of Porfimer Sodium and/or light.

The following will be considered Dose Limiting Toxicities (DLT):

• Urinary symptoms grade 3, or more over 12 weeks duration (see section 7 for toxicity grading)

• Loss of > 50% of baseline bladder volume

• Clinical decision of investigator or patient to discontinue due to toxicity.

Efficacy will be assessed on the basis of the following criteria:

• Complete Response: cystoscopy with biopsy and/or cytology without evidence of cancer.

• Partial Response: normal cystoscopy and biopsies, if obtained, but persistent positive or suspicious cytology localized to the bladder; or, for patients with CIS, > 50% reduction in extent of CIS.

• Persistent/Recurrent Disease: persistent or recurrent cancer of the same or lesser stage and grade as at enrollment without obvious increase in tumor burden.

• Progression: cancer of any greater stage or grade than at enrollment or obvious increase in tumor burden.

Referred patients will undergo post-PDT cystoscopy by the referring Urologists, who will transmit the results to the study site in Gainesville,Fl.

5. Symptoms will be assessed for one month following each WBPDT by weekly telephone contact.

6. Urine and blood for cytokines will be obtained before each treatment and possibly twice afterwards and stored -80oF for analysis later.

7. Biopsy specimen samples from tumor and normal bladder may be obtained at cystoscopy and stored for later analysis for biomarkers.

8. Patients will be followed for toxicity, disease status, urinary tract symptoms, and survival.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 22
• Est. completion date: March 2011
• Est. primary completion date: April 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Pathological diagnosis of bladder cancer, non muscle invasive

• Recurrent after at least one course of standard intravesical therapy after transurethral resection (TURBT).

• Maximum debulking of tumor by TURBT/fulguration

• One or more of the following:

• Contraindications to conventional intravesical therapy, including patient's refusal.

• Positive or suspicious urine cytology localized to the bladder

• Prior intravesical therapy and persistent atypia.

• Premalignant (diffuse squamous metaplasia or malakoplakia) lesions.

• Bladder capacity greater or equal to 150 cc.

• No contraindications to an appropriate anesthesia or analgesia.

• Karnofsky's performance status > 50.

• Patients must sign an informed consent form in accordance with the Institution's Review Board and FDA 21 CFR Part 50.

• Female patients must be practicing a medically acceptable form of birth control or be sterile or postmenopausal.

Exclusion Criteria:

• Pregnant or nursing mother.

• Known hypersensitivity to porphyrins.

Study Design

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Superficial Bladder Cancer
• Urinary Bladder Neoplasms

Intervention

Procedure:
• Whole bladder laser light treatment as an alternative to radical cystectomy
The drug,Photofrin,at the dose of 1.5 mg/kg is infused intravenously two days prior to performing whole bladder laser light (630 nm) treatment.

Drug:
• Photofrin
The drug,Photofrin,at the dose of 1.5 mg/kg is infused intravenously two days prior to performing whole bladder laser light (630 nm) treatment.

Locations

Country	Name	City	State
United States	Malcom Randall NF/SG Veterans Administration Health System	Gainesville	Florida

Sponsors (3)

Lead Sponsor	Collaborator
North Florida/South Georgia Veterans Health System	Axcan Pharma, North Florida Foundation for Research and Education

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Dose Limiting Toxicity		18 months	Yes
Secondary	Disease progression		18 months	No