Sun Damaged Skin Clinical Trial
Official title:
An Assessment of TLR4 and TOPK/PRPK Signaling in Sun Damaged Human Skin Acutely Exposed to Solar Simulated Light
The purpose of this project is to obtain clinical data, including skin samples, that will help investigators evaluate changes occurring in sun damaged human skin as a result of light that simulates sun exposure (Solar Simulated Light). Of specific interest are the molecular targets for cancer prevention. Molecular targets are the parts of the body's cells that have been shown to play a role in causing or preventing cancer and which scientists seek to affect in a way that may slow or eliminate the development of cancer.
The aim of this study is to assess TLR4 and TOPK/PRPK signaling in sun damaged human skin acutely exposed to solar simulated light and to validate this clinical model prior to intervention with therapeutic skin cancer prevention approaches. Acute solar simulated light exposure will be evaluated in sun damaged skin to determine the level of activation of the targeted pathways using reverse-phase protein array (LCM-RPPA) analysis and immunohistochemistry (IHC). ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04181476 -
Efficacy Evaluation of Products Against Long Wavelength Ultraviolet A1 and Visible Light Induced Biological Effects
|
Phase 2 | |
Completed |
NCT05300542 -
Efficacy Study of a Novel Skin Health Product to Reduce an UVB Induced Erythema
|
N/A | |
Completed |
NCT05865431 -
Singlet Oxygen Quantification After Skin Exposure to Ultraviolet A (UVA) Light
|
N/A | |
Completed |
NCT05926791 -
Photoprotective Effects of a SPF50+ Sunscreen on Skin Genotoxicity Induced by Repeated Chronic Outdoor Sun Exposure
|
||
Completed |
NCT05162300 -
Same-Day Combination of VI Peel and Botox for Correction of Sun Damage, Fine Lines and Wrinkles
|
Phase 4 | |
Completed |
NCT03110159 -
DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipients
|
Phase 1/Phase 2 | |
Completed |
NCT03006185 -
Laser and Microdermabrasion Before Photodynamic Therapy for Actinic Keratoses in Field-cancerized Skin
|
Phase 2 | |
Enrolling by invitation |
NCT03007589 -
Natural Sunlight Protection and Simulated Sunlight Protection Offered by Sunscreens and Fabrics
|
N/A |