Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Relation between levels of peripheral inflammatory markers and suicide attempt |
Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) between participants with and without suicide attempt |
baseline |
|
Primary |
Relation between levels of peripheral inflammatory markers and suicide attempt |
Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) between participants with and without suicide attempt |
on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Change from baseline in peripheral inflammatory marker levels for healthy control group |
Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) between baseline and discharge time points |
baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Change from baseline in peripheral inflammatory marker levels for suicide attempt study group |
Comparison of the levels of peripheral inflammatory markers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) between baseline and discharge time points |
baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Relation between levels of peripheral inflammatory markers and Columbia Suicide Severity Rating Scale scores |
Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) and suicide ideation intensity (scores on Columbia Suicide Severity Rating Scale) |
on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Relation between levels of peripheral inflammatory markers and Suicidal Ideation Questionnaire scores |
Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) and suicide ideation intensity (Suicidal Ideation Questionnaire) |
on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Relation between levels of peripheral inflammatory markers and depression |
Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) and depression (scores on Children's Depression Rating Scale, Revised) |
on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Relation between levels of peripheral inflammatory markers and anxiety |
Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) and anxiety (scores on Multidimensional Anxiety Scale for Children, 2nd Ed) |
on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Relation between levels of peripheral inflammatory markers and trauma |
Studying relation between inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) and trauma (scores on Adverse Childhood Experiences Questionnaire (ACE) and Life Events Checklist-5 (LEC-5)) |
on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Changes in peripheral inflammatory marker levels predicting changes in Columbia Suicide Severity Rating Scale scores |
Peripheral inflammatory markers: S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid |
baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Changes in peripheral inflammatory marker levels predicting changes in Suicidal Ideation Questionnaire scores |
Peripheral inflammatory markers: S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid |
baseline and on the date of discharge from hospital inpatient unit (average length of admission = 5 days) |
|
Secondary |
Peripheral inflammatory markers as a risk factor for suicide attempts |
Studying inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt risk factors (frequency of attempts) |
up to 12 months post-discharge |
|
Secondary |
Peripheral inflammatory markers as a risk factor for suicide ideation intensity (scores on Columbia Suicide Severity Rating Scale) |
Studying inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Columbia Suicide Severity Rating Scale) |
up to 12 months post-discharge |
|
Secondary |
Peripheral inflammatory markers as a risk factor for suicide ideation intensity (scores on Suicidal Ideation Questionnaire) |
Studying inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Suicidal Ideation Questionnaire) |
up to 12 months post-discharge |
|
Secondary |
Peripheral inflammatory markers as a risk factor for suicide attempt re-admission |
Studying inflammatory biomarkers (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt re-admission risk factors (frequency of re-admissions) |
up to 12 months post-discharge |
|
Secondary |
Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide attempts |
Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt risk factors (frequency of attempts) |
up to 12 months post-discharge |
|
Secondary |
Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide ideation intensity (scores on Columbia Suicide Severity Rating Scale) |
Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Columbia Suicide Severity Rating Scale) |
up to 12 months post-discharge |
|
Secondary |
Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide ideation intensity (scores on Suicidal Ideation Questionnaire) |
Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide ideation intensity risk factors (scores on Suicidal Ideation Questionnaire) |
up to 12 months post-discharge |
|
Secondary |
Change in peripheral inflammatory marker levels from baseline to discharge as a risk factor for suicide attempt re-admission |
Studying the change in inflammatory biomarkers from baseline to discharge (S100B, IL-6, IL-1ß, TNF-a, kynurenic acid, quinolinic acid, and picolinic acid) as suicide attempt re-admission risk factors (frequency of re-admissions) |
up to 12 months post-discharge |
|
Secondary |
Clinical assessment values that predict suicide attempts |
Studying which clinical assessments can help predict suicide attempt (frequency of attempts) |
up to 12 months post-discharge |
|
Secondary |
Clinical assessment values that predict suicide ideation intensity scores on Columbia Suicide Severity Rating Scale |
Studying which clinical assessments can help predict suicide ideation intensity scores on Columbia Suicide Severity Rating Scale |
up to 12 months post-discharge |
|
Secondary |
Clinical assessment values that predict suicide ideation intensity scores on Suicidal Ideation Questionnaire |
Studying which clinical assessments can help predict suicide ideation intensity scores on Suicidal Ideation Questionnaire |
up to 12 months post-discharge |
|
Secondary |
Clinical assessment values that predict suicide attempt re-admission |
Studying which clinical assessments can help predict suicide attempt re-admission (frequency of re-admissions) |
up to 12 months post-discharge |
|
Secondary |
Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide attempts |
Studying which combination of inflammatory biomarkers and clinical predictors best predicts future suicide attempts (frequency of attempts) |
up to 12 months post-discharge |
|
Secondary |
Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide ideation intensity scores on Columbia Suicide Severity Rating Scale |
Studying which combination of inflammatory biomarkers and clinical predictors best predicts suicide ideation intensity scores on Columbia Suicide Severity Rating Scale |
up to 12 months post-discharge |
|
Secondary |
Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide ideation intensity scores on Suicidal Ideation Questionnaire |
Studying which combination of inflammatory biomarkers and clinical predictors best predicts suicide ideation intensity scores on Suicidal Ideation Questionnaire |
up to 12 months post-discharge |
|
Secondary |
Peripheral inflammatory markers in combination with clinical assessments as predictors for suicide attempt re-admission |
Studying which combination of inflammatory biomarkers and clinical predictors best predicts future suicide attempt re-admissions (frequency of re-admissions) |
up to 12 months post-discharge |
|