Cognitive Inhibition, Psychosocial Interactions and Suicide Attempt in Elderly

Suicide Clinical Trial

— OBSUIVAL  

Official title:

Cognitive Inhibition Impairment and Suicide Attempt in Elderly: Eye Tracking Characterization and Impact of Psychosocial Interactions

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT02858427
• Other study ID #: P/2016/288
• Status: Recruiting
• Phase: N/A
• First received: August 1, 2016
• Last updated: October 12, 2017
• Start date: February 6, 2017
• Est. completion date: February 6, 2020

Study information

• Verified date: October 2017
• Source: Centre Hospitalier Universitaire de Besancon
• Contact: julie monnin, PhD
• Phone: 0033381218543
• Email: jmonnin[@]chu-besancon.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.

Description:

2 groups of patients will be studied: in the first group, depressed patients with a history of suicide attempt will be included whereas in the second group, depressed patients without a history of suicide attempt will be included.

For each group, the cognitive inhibition will be assessed trough an eye tracker task (antisaccade).

Both groups will also be compared on their neuropsychological characteristics and the quality of social interactions of participants.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 36
• Est. completion date: February 6, 2020
• Est. primary completion date: August 6, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• major depressive disorder according to Diagnostic ans Statistical Manual (DSM) V

• group 1: with a history of suicide attempt

• group 2: without a history of suicide attempt

Exclusion Criteria:

• other psychiatric disease

• guardianship

Related Conditions & MeSH terms

• Suicide
• Suicide, Attempted

Intervention

Behavioral:
• eye tracking
several oculomotor parameters will be recorded using vide-oculography techniques (eye tracking) trough different tasks: saccade, antisaccade, and picture scanning. Saccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the red dot appearing on the periphery of the screen. Prosaccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the opposite side relative to the red dot appearing on the periphery of the screen. Picture Scanning: participant is instructed to freely watch pictures with different emotional valence.
• neuropsychological assessement
the neuropsychological assessment aims to identify any impairment of executive functioning through several tasks: Mini mental state examination (mmse), isaac set test (STI) trail making test (TMT A and B), Grober test, Stroop test, verbal fluency, Go No Go task, memory impairment screen (MIS), picture naming test (DO30), copying figure test, digit span and categorical matching test.
• psychiatric assessment
this evaluation aims to characterize the mental status of the patient. Different scales will be used: Montgomery and ASberg depression rating scale (MADRS), Columbia-suicide severity rating scale (C-SSRS), Beck depression inventory (BDI), Barratt impulsiveness scale (BIS-10), Buss and Durkee Hostility Inventory (BDHI), Balloon, analogue risk task (BART), Iowa gambling task (IGT), and Childhood trauma questionnaire (CTQ).
• sociological interview
this interview aims to characterize social interactions of the patients, their duration, their evolution and the perception of each participant on this subject.

Locations

Country	Name	City	State
France	CHS Bavilliers	Bavilliers
France	CHU Besancon	Besancon	Doubs

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Besancon

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	neuropsychological test score		1 month max. after inclusion
Primary	antisaccade error rate		1 month max. after inclusion
Secondary	saccade accuracy	distance between the eye position at the end of the first saccade, and the ideal position to engage the target in central vision	1 month max. after inclusion
Secondary	saccadic intrusion	gaze deviation into a saccade greater than 3° during visual fixation	1 month max. after inclusion
Secondary	maximal speed of the gaze	maximum speed of visual tracking without triggering any saccade	1 month max. after inclusion
Secondary	saccade reaction time		1 month max. after inclusion
Secondary	fixation duration on pictures		1 month max. after inclusion
Secondary	social interaction quality score		6 month max. after inclusion