Suicidal Behaviors Clinical Trial
Official title:
Clinical and Neural Changes Associated With Dialectical Behavioral Therapy in Adolescents With Suicidal Behaviors
Suicidal behaviors among adolescents represents a public health problem due to its high
prevalence and its low predictability. It is also known that brain development continues
during adolescence, therefore, a therapeutic intervention during this period might
propitiate neural changes that might favor the emotional regulation involved in suicidal
behaviors. Dialectical Behavioral Therapy has proved to be effective regarding this problem.
For this reason, the investigators aimed to study the clinical, neuropsychological and
neural effects of Dialectical Behavioral Therapy in adolescents with suicidal behaviors.
Suicidal behaviors represent a public health problem due to its high prevalence and its low
predictability. At a neurological level, higher vulnerability for suicidal behavior has been
related to a frontostriatal-cingulum tract dysfunction as well as attention, memory and
executive deficits. It is also known that brain development continues during adolescence,
therefore, a therapeutic intervention during this period might propitiate neural changes
that could favor the emotional regulation involved in suicidal behaviors. Specifically,
Dialectical Behavioral Therapy has proved to be effective regarding this problem.
The investigators hypothesis is that DBT (Dialectical Behavioral Therapy) will improve
clinical symptoms associated with suicidal behaviors, as well as the neural
interconnections, which will result not only in structural and functional connectivity
changes, but also in a better cognitive functioning. The investigators aimed to investigate
the clinical, neuropsychological, and neural effects of Dialectical Behavioral Therapy in
adolescents with suicidal behaviors.
The investigators method is a randomized, controlled study that includes 30 patients with
suicidal behaviors and 15 healthy controls between the ages of 12 and 18 years. Patients
were assigned to one of two groups (randomized): DBT and Regular Support Therapy. Clinical
and neuropsychological evaluations were performed before and after the treatment for both
patient groups. Additionally, Structural MRI data sets, diffusion-tensor imaging (DTI) and
Functional Connectivity (Resting State fmri) were acquired for all patients and controls at
baseline and after treatment. Initial characteristics will be compared between the three
groups, and the investigators will also compared clinical, neuropsychological and imaging
measures before and after the treatment.
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