Ventricular Tachycardia Clinical Trial
Official title:
Intravenous Infusion of n-3 Polyunsaturated Fatty Acids and Ventricular Tachycardia in Patients With Implantable Cardioverter Defibrillator (ICD)
The long-chain n-3 polyunsaturated fatty acids (PUFA), eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA), appear to offer protection against sudden cardiac death and
ventricular arrhythmias. EPA and DHA are essential fatty acids which are incorporated into
cellular membranes after regular ingestion of fatty fish or fish oil.
This study investigates a possible acute effect of intravenous infusion of n-3 PUFA on
inducibility of ventricular tachycardia (VT) in patients with an ICD-pacemaker.
The hypothesis is that an acute rise in the concentration of n-3 PUFA in plasma will
increase the electric stability of the myocardial cells, so that VT is more difficult to
induce.
In a randomized, placebo-controlled, double-blind, crossover study, a lipid emulsion with a
high content of n-3 PUFA (or placebo: isotonic saline) will be administered intravenously
before a non-invasive electrophysiologic examination performed via the ICD and following a
predefined protocol.
The main outcome is inducibility of VT. If sustained VT is induced in a patient after both
n-3 PUFA and placebo, the strength of the required stimulus after n-3 PUFA and after placebo
is compared.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
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