The Effects of a Train High, Sleep Low Strategy

Substrate Utilization Clinical Trial

Official title:

The Effects of a Train High, Sleep Low Strategy on Performance, Substrate Utilization and Muscular Adaptations in Moderately Trained Cyclists

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03045588
• Other study ID #: Sleep low
• Status: Completed
• Phase: N/A
• Start date: October 1, 2016
• Est. completion date: October 10, 2018

Study information

• Verified date: October 2018
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The investigators will examine the long-term effects of a combined training and diet intervention that, acutely, increases fat oxidation during exercise. This is done with a 4 week intervention study with moderately trained cyclists. Performance is tested pre and post intervention and muscle biopsies are obtained.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: October 10, 2018
• Est. primary completion date: December 20, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• 18-45 years

• VO2-max>55 ml/kg/min

• No smokers

• Training 6 hours per week (cycling)

• Training experience for more than 3 years.

Exclusion Criteria:

• Less than 2 g carbohydrate/kg/day

Related Conditions & MeSH terms

• Cycling Performance
• Muscular Adaptations
• Substrate Utilization

Intervention

Other:
• Combined exercise and diet intervention
Both groups exercise 6 times per week in 4 weeks conducted as 3 evening and 3 morning sessions per week. Both groups receive dietary products to be consumed immediately before and after each evening and morning session, respectively. One group conduct morning sessions in a fasted state, the other conduct the morning sessions in a fed state. Performance pre and post is measured, and muscle biopsies are obtained.

Locations

Country	Name	City	State
n/a

Sponsors (2)

Lead Sponsor	Collaborator
University of Aarhus	Team Denmark

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time trial performance measured in Watts	30 min time trial after 90 minutes of intensive cycling. The average amount of Watts during the 30 minutes will be measured.	Change from Baseline and after 4 weeks of training
Secondary	Protein expression in skeletal muscle tissue	Amount of mitochondrial proteins and enzymes will be measured with a Western Blotting technique	Baseline and after 4 weeks of training
Secondary	The absolute amount of carbohydrate and fat which is metabolised during morning exercise, measured in grams/minute	Fat and carbohydrate oxidation during exercise measured and estimated with indirect calorimetry.	Baseline and after 4 weeks of training