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Nicotine Replacement Therapy in the Intensive Care Unit — NicGoWell  

Delirium Clinical Trial

Official title:
Nicotine Replacement Therapy in the Intensive Care Unit: a Randomized, Controlled Pilot Study

Clinical Trial Summary

The purpose of this study is to determine whether transdermal nicotine replacement therapy is safe and effective for treating nicotine withdrawal symptoms in the critically ill smoking patient.

Clinical Trial Description

Cigarette smoking remains the leading cause of preventable disease and premature death worldwide. There are about 1.2 billion smokers in the world, half of whom will die from diseases caused by smoking. Smoking causes 5 million deaths per year, and if present trends continue, 10 million smokers per year are projected to die by 2025.

Furthermore, abstinence from the highly addictive tobacco products can lead to withdrawal symptoms. Although these symptoms are non-life threatening in healthy and hospitalized adults they are not well described in the mechanically ventilated active smoking patient.

Retrospective studies found a higher, lower or equal mortality in critically ill patients receiving nicotine replacement therapy compared to patients receiving no nicotine replacement.

Because of these conflicting results and the absence of a randomized controlled trial studying the efficacy and safety of transdermal nicotine replacement therapy in the critically ill smoking patient a clinical study will be conducted. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01362959
Study type Interventional
Source Gelderse Vallei Hospital
Contact
Status Completed
Phase Phase 4
Start date June 2012
Completion date August 2016
View Details
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