Substance Abuse Clinical Trial
Official title:
The Effects of Doxazosin on the Cardiovascular and Subjective Effects of Cocaine
The purpose of the study is to asses the potential interactions between intravenous cocaine and doxazosin in cocaine dependent volunteers who are not seeking treatment. The study will evaluate the effects of doxazosin on the cardiovascular and subjective effects of cocaine in a human laboratory study.
Primary Objective: The primary objective is to determine the safety of treatment with
doxazosin in cocaine-dependent volunteers by examining hemodynamic and subjective effects of
administration of ascending doses of cocaine (0, 20mg, and 40mg) and a placebo dose during
treatment with doxazosin.
Secondary Objectives: To evaluate the effect of doxazosin on the pharmacokinetics of
intravenously administered cocaine; To determine effects of treatment with doxazosin, as
compared to placebo, on subjective effects produced by administration of cocaine or placebo.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
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