Biometry of Occult Lens Subluxation Misdiagnosed as Primary Acute Angle Closed Glaucoma

Subluxation of Lens Clinical Trial

Official title:

Biometric Indicators of Eyes With Occult Lens Subluxation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03752710
• Other study ID #: Tianjin LS study
• Status: Completed
• Start date: January 2016
• Est. completion date: December 2017

Study information

• Verified date: November 2018
• Source: Tianjin Medical University Eye Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In this work, we evaluated the biometry data of lens subluxation inducing acute angle closure which were misdiagnosed as primary angle closure at the first visit, and compared with the data of chronic angle closure glaucoma, cataract, primary acute angle closure.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 183
• Est. completion date: December 2017
• Est. primary completion date: December 2017
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

ASAC-LS was diagnosed according to the following criteria, including sudden pain in the eye, decreased vision with or without nausea and vomiting. Slit lamp microscopy reveals phacodonesis, lens inclination or vitreous herniation into the anterior chamber, central and peripheral shallow anterior chamber, and asymmetric iris bulge. All patients were confirmed during the surgery to have LS.

APACG was diagnosed with the following criteria6, 7 8, including substantially elevated IOP and closed angle, acute eye pain, blurred vision, or nausea and vomiting. More importantly, ischemic injury caused by acute ocular hypertension, ciliary or mixed congestion, corneal edema, and glaucoma flecks should be detected.

The diagnostic criteria of CPACG included narrow angle with anterior synechiae of varying widths, IOP > 22 mmHg, and glaucomatous optic disc damage and visual field shrinkage9-11 The angle closure should be more than two quadrants, yet there was no ischemic injury in the anterior segment caused by acute ocular hypertension.

Exclusion criteria were history of laser peripheral iridotomy or peripheral iridectomy, glaucoma filtration surgery, angle closure caused by ocular trauma, uveitis, neovascularization or lens swelling or hyper mature lens. The patients with acute angle closure in both eyes were excluded. The subjects in which Lenstar LS900 examination could not be performed because of severe lens opacity or corneal edema were also not included in the study.

Related Conditions & MeSH terms

• Lens Subluxation
• Subluxation of Lens

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Tianjin Medical University Eye Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Eye anterior segment biometry	Anterior segment biometry measure by Lenstar LS900	1 day
Primary	Intraocular pressure	Intraocular pressure was measured by Goldmann tonometer	1 year
Primary	visual acuity	visual acuity before and after surgery	1 year