Subfertility Clinical Trial
Official title:
Evaluation of the Optimal Dose of GnRH Agonist for Triggering Final Oocyte Maturation in High Risk OHSS Patients Undergoing Ovarian Stimulation for IVF With GnRH Antagonists and Recombinant FSH.
The present study aims to investigate whether the dosage of the GnRH agonist used for triggering final oocyte maturation affects the maturity of the oocytes retrieved in high risk for OHSS patients undergoing ovarian stimulation for IVF using GnRH antagonists and recombinant FSH.
Three different doses of GnRH agonist (0.1mg, 0.2mg or 0.4 mg) will be used randomly to
trigger final oocyte maturation. The primary outcome measure will be the percentage of
mature oocytes retrieved.
Secondary outcomes will include: number of oocytes retrieved, oocyte recovery rate (number
of oocytes retrieved/ number of follicles >11mm in diameter on the day of triggering),
fertilization rates and OHSS occurrence.
Serum LH, FSH, E2, PRG levels will be assessed at 8-36 hours following agonist
administration and on days 3-4-7-10 after triggering final oocyte maturation.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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