Subfertility Clinical Trial
Official title:
Food Lifestyle and Fertility Outcome
In vitro fertilization (IVF) is an assisted reproductive technique to achieve pregnancy in
subfertile couples of which the average success rate is only 25%. Mild ovarian stimulation
treatment yields less oocytes, has less adverse effects but has a comparable clinical
outcome compared to conventional stimulation treatment. There is high inter- and intra
person variability in ovarian response and fertility outcome parameters after stimulation
treatment and little is known about explanatory variables herefore.
Nutrition and in particular folate, or its synthetic derivative folic acid, is a B-vitamin
which has been widely asssociated with reproductive outcome and subfertility. Therefore, in
this study we aim to investigate the influence of preconception nutrition and folic acid use
on ovarian response after mild/conventional stimulation treatment and to identify biomarkers
in the follicular fluid which can indicate oocyte quality and other fertility outcomes.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
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