LH/HCG Receptor Expression and Retrieval Rates

Subfertility Clinical Trial

Official title:

Association of LH/HCG Receptor Expression and Retrieval Rates at Oocyte Pick up.

Clinical Trial Details — Status: Suspended

Administrative data

• NCT number: NCT00438373
• Other study ID #: UHR-1
• Status: Suspended
• Phase: N/A
• First received: February 21, 2007
• Last updated: February 25, 2015
• Start date: January 2007
• Est. completion date: January 2016

Study information

• Verified date: February 2015
• Source: Aristotle University Of Thessaloniki
• Contact: n/a
• Is FDA regulated: No
• Health authority: Greece: Ministry of Health and Welfare
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG administration or the day of oocyte retrieval and the retrieval rates at oocyte pick up

Description:

The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG or the day of oocyte retrieval and the retrieval rates at oocyte pick up.

For this purpose, m-RNA copy numbers will be assessed in the blood serum of patients undergoing ovarian stimulation for IVF on different days.

Furthermore, detailed ultrasound scans will be perfomed, as well as assesment of hormonal levels during ovarian stimulation.

Recruitment information / eligibility

• Status: Suspended
• Enrollment: 100
• Est. completion date: January 2016
• Est. primary completion date: January 2016
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 18 Years to 39 Years

Eligibility

Inclusion criteria:

• Age <39 years,

• Body mass index (BMI) between 18 and 29 kg/m2,

• Presence of both ovaries,

• FSH levels <10 IU/l.

Exclusion criteria:

• Endometriomas,

• Polycystic ovarian syndrome.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Subfertility

Locations

Country	Name	City	State
Greece	Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital	Thessaloniki

Sponsors (2)

Lead Sponsor	Collaborator
Aristotle University Of Thessaloniki	University of Athens

Country where clinical trial is conducted

Greece, 

References & Publications (2)

Patsoula E, Loutradis D, Drakakis P, Kallianidis K, Bletsa R, Michalas S. Expression of mRNA for the LH and FSH receptors in mouse oocytes and preimplantation embryos. Reproduction. 2001 Mar;121(3):455-61. — View Citation

Patsoula E, Loutradis D, Drakakis P, Michalas L, Bletsa R, Michalas S. Messenger RNA expression for the follicle-stimulating hormone receptor and luteinizing hormone receptor in human oocytes and preimplantation-stage embryos. Fertil Steril. 2003 May;79(5):1187-93. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	LH/hCG receptor expression		at oocyte retrieval	No