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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02389634
Other study ID # 10BN048
Secondary ID
Status Completed
Phase
First received
Last updated
Start date September 2010
Est. completion date October 25, 2019

Study information

Verified date April 2024
Source St. Joseph's Hospital and Medical Center, Phoenix
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of the study is to identify novel genetic and protein markers for the process of cerebral vasospasm following aneurysmal subarachnoid hemorrhage.


Description:

Cerebral vasospasm is a recognized and poorly understood complication for many patients who have aneurysmal subarachnoid hemorrhage. Constriction of the cerebral arterial vasculature occurs as free subarachnoid blood under high pressure comes into contact with the surfaces of vessels, particularly in the basal cisterns. However, the exact pathophysiology of vasospasm is unknown. Morbidity and mortality rates for vasospasm are high despite improvements in management. Excluding the initial hemorrhage, cerebral vasospasm is recognized as the main cause of substantial disability and death. Cerebral vasospasm kills 7% of patients, and causes severe deficit in another 7%. Cerebral vasospasm almost never occurs before day 3, has maximal incidence at days 6-8, and rarely occurs after day 17. The disorder is clinically characterized by confusion or decreased consciousness with focal neurological deficit. Experimental evidence suggests that red blood cell hemolysis and subsequent release of oxygen, hemoglobin, reactive oxygen species, and other as yet undescribed mediators are necessary for the development of vasospasm. The goal of this study is to use modern tools of genomics to identify novel molecular markers for the process of vasospasm by studying the release of micro ribonucleic acids (RNA) that are secreted into the cerebrospinal fluid following the initiation of vasospastic cascades. Micro RNA's have recently been identified as important regulators of many cellular processes including cell cycle progression, proliferation, tumor suppressors, oncogenes, and regulators of metabolic pathways. The researchers propose to study the levels of annotated micro RNA's in the cerebrospinal fluid (CSF) of patients who present with subarachnoid hemorrhage from presentation through the hospital stay. The researchers will correlate the level of these micro RNA's with patient clinical presentation, including transcranial Doppler measurements, Glasgow Coma Scale score, vital signs, and angiographic studies. It is well established that the process of vasospasm occurs over the course of many days. Long before vasospasm becomes clinically evident, cellular processes causing spasm are in action and the researchers hope to identify micro RNA mediators of these processes using high throughput screening methods.


Recruitment information / eligibility

Status Completed
Enrollment 50
Est. completion date October 25, 2019
Est. primary completion date October 25, 2019
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Adult patients with aneurysmal subarachnoid hemorrhage within 24-hours of bleed. - Receive either open vascular clipping or endovascular coiling. Exclusion Criteria: - Patients under 18 years of age. - Patients arriving at the hospital >24-hours post-hemorrhage. - Patients who are not candidates for further care.

Study Design


Locations

Country Name City State
United States Barrow Neurological Institute at St. Joseph's Hospital and Medical Center Phoenix Arizona

Sponsors (2)

Lead Sponsor Collaborator
St. Joseph's Hospital and Medical Center, Phoenix Translational Genomics Research Institute

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary Identification of vasospasm via microRNA mediators prior to clinically evident signs and symptoms Identification of vasospasm via microRNA mediators prior to clinically evident signs and symptoms 30 days
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