Subarachnoid Hemorrhage Clinical Trial
Official title:
Effect of Red Blood Cell Transfusion on Brain Metabolism in Patients With Subarachnoid Hemorrhage
The purpose of this study is to determine if giving blood transfusions to anemic patients with subarachnoid hemorrhage will reduce their chances of having a stroke from vasospasm.
Status | Completed |
Enrollment | 44 |
Est. completion date | August 2015 |
Est. primary completion date | August 2015 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: 1. Aneurysmal SAH confirmed by angiography 2. Hemoglobin < 12.5 gm/dl 3. One of the following: - Considered at increased risk for vasospasm by care team - Angiographic vasospasm - Delayed ischemic deficit 4. Able to be studied within 2 weeks after subarachnoid hemorrhage Exclusion Criteria: 1. Active Coronary Artery Disease 2. Severe congestive heart failure 3. Jehovah's witness 4. Unable to obtain appropriately matched blood 5. Other contraindications for transfusion 6. Pregnancy |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
United States | Washington University Medical Center | St Louis | Missouri |
Lead Sponsor | Collaborator |
---|---|
Washington University School of Medicine | National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Dhar R, Zazulia AR, Videen TO, Zipfel GJ, Derdeyn CP, Diringer MN. Red blood cell transfusion increases cerebral oxygen delivery in anemic patients with subarachnoid hemorrhage. Stroke. 2009 Sep;40(9):3039-44. doi: 10.1161/STROKEAHA.109.556159. Epub 2009 — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Percent of brain regions with low oxygen delivery before and after transfusion | 1 hour | No | |
Secondary | Relationship between change in oxygen delivery and angiographic vasospasm | 1 hour | No |
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