Characteristics of Idiopathic Familial Speech Disorders

Status Completed

Clinical Trial Summary

According to studies, speech disorders with unknown causes (idiopathic) affect approximately 5% of the population at some point in their life. Some of these disorders like, stuttering and cluttering, are known for being detected early, during speech development.

Stuttering is characterized by sound and syllable repetitions and consonant/vowel prolongations. When stuttering is moderate to severe, it can interfere with a person's job and social activities.

Speech articulation disorders are characterized by omissions, or substitutions of speech sounds. The speech of a person who clutters is often difficult to understand. People are often unaware of the errors they make when speaking causing treatment of the condition to be very difficult.

The purpose of this research is to study an extended family whose members exhibit a pure form of speech articulation disorders

In addition, the study will use data and information gathered from the study and use it to develop guidelines (criteria) for defining and differentiating patients with speech disorders.

Clinical Trial Description

Objective:

Our objective is to determine which factors are involved in the development of stuttering and familial phonological processing disorder and are associated with a familial pattern of inheritance.

Study population: The study population is comprised of 8 groups:

1. Children and adults with persistent developmental stuttering;

2. Unaffected siblings of the individuals affected with developmental stuttering or recovered from stuttering

3. Children and adults who have recovered from developmental stuttering;

4. Children and adults with persistent familial phonological processing disorders (FPPD);

5. Unaffected siblings of the individuals affected with FPPD or have recovered from FPPD

6. Children and adults who have recovered from FPPD;

7. Unaffected siblings of the individuals who have recovered from FPPD;

8. Children and adults with normal speech and language development who will comprise the control groups.

Design: A Natural history design will be used to compare affected and unaffected family members with healthy volunteers with normal speech and language.

Outcome Measures: Genetic markers and pedigree analyses will be used to test familial inheritance patterns. Speech and language development will be compared using indices of speech perception, auditory perception, self monitoring of one's own speech, language complexity, motor complexity, speech learning, phonological processing and verbal/nonverbal memory. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00001551
Study type	Observational
Source	National Institutes of Health Clinical Center (CC)
Contact
Status	Completed
Phase	N/A
Start date	May 22, 1996

View Details

See also
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Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.