Clinical Trials Logo

Clinical Trial Summary

According to the latest estimates, 144 million children under age five experience growth faltering. Early life growth faltering or stunting is predictive of a wide array of negative long-term outcomes, including reduced adult height and productivity, diminished health and reduced lifetime incomes. This study builds on a previous pilot study, which suggests that providing parents with tools to measure children's growth at home may be an effective way to prevent early life growth faltering. The objectives of this study are to assess 1) the impact of growth charts on early childhood linear growth; and 2) whether the impact of growth charts can be increased with the provision of food supplements to parents.

Clinical Trial Description

More than 250 million children under the age of five are currently estimated to not reach their developmental potential due to poverty, malnutrition and infectious diseases. According to the latest estimates, 21% of children under age 5 in LMICs are more than two standard deviations shorter than the global reference median and thus considered stunted according to WHO guidelines. Early life growth faltering interferes with children's ability to learn and has been associated with reduced subsequent development and physical growth. Stunting has also been linked to delayed school enrollment, reduced educational attainment, poor health, and decreased well-being. There is a growing consensus among scientists, the global public health and development community as well as among governments that addressing stunting is a top priority for promoting children's development and well being, and for increasing children's future economic potential. While a large literature has highlighted the importance of favorable environmental and socioeconomic factors for the prevention of early growth faltering, effective interventions to reduce growth faltering in low income settings remain scarce. Among families of affected children, stunting often goes unrecognized in communities where growth faltering is common. Even children with substantial delays in their physical development may be perceived as of normal size in comparison to peer children in their community. In many Low and Middle Income Countries (LMICs), height measurements are not routinely conducted as part of child health checkups. In Zambia, many parents were found to be unaware of their child's growth deficits, which makes it difficult for them to act to combat chronic malnutrition and stunting. In a previous pilot study, the investigator team found that simple growth charts installed at children's homes can be an effective tool for increasing parental awareness of children's nutritional need and growth trajectories. The objective of this trial is thus to rigorously assess these growth charts through a cluster-randomized controlled trial to be conducted in three districts of Zambia. Given that larger improvements in height may only be possible with additional nutritional input in this setting, the trial will also assess the extent to which early life growth can be improved through the provision of lipid-based nutrient supplements (LNS). The overall objective of this project is to assess the impact of growth charts as well as nutritional supplements on children's physical growth in a representative sample of Zambia communities. This larger objective can be divided into three specific aims: Specific Aim 1: Assess the impact of growth charts installed in children's homes on children's physical growth. Specific Aim 2: Assess the extent to which growth trajectories can be modified through the provision of LNS. Specific Aim 3: Assess the extent to which growth trajectories can be modified through the joint provision of LNS and home-installed growth charts ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05120427
Study type Interventional
Source Swiss Tropical & Public Health Institute
Status Active, not recruiting
Phase N/A
Start date September 1, 2020
Completion date June 30, 2023

See also
  Status Clinical Trial Phase
Completed NCT03268902 - Early Life Interventions for Childhood Growth and Development In Tanzania Phase 2/Phase 3
Active, not recruiting NCT03683667 - Protein Plus: Improving Infant Growth Through Diet and Enteric Health Phase 2/Phase 3
Completed NCT01562379 - Complementary Food Supplements for Reducing Childhood Undernutrition Phase 2/Phase 3
Not yet recruiting NCT03399617 - SPOON: Sustained Program for Improving Nutrition - Guatemala N/A
Recruiting NCT05100550 - Family-based Health Education Program and Zinc Supplementation for Stunted Mother N/A
Active, not recruiting NCT02532816 - Nutrient-Dense Complementary Foods on Catch-up Growth and Nutritional Status of Stunting Children N/A
Completed NCT01553552 - Schistosomiasis Effect on Response to Vaccines, Anaemia and Nutritional Status of Children of Northern Senegal N/A
Active, not recruiting NCT04579328 - Impact of Life-size Growth Charts on Understanding of Stunting N/A
Completed NCT03647553 - The Nash-wo-Numa (Childhood Growth & Development) Study
Completed NCT03847662 - Scaling up Small-Scale Food Processing to Promote Food Security Among Women Farmers in Rural Vietnam
Completed NCT04640389 - Rural-urban Disparities in the Nutritional Status of Younger Adolescents in Tanzania.
Completed NCT00970866 - Efficacy of Lipid-Based Nutrient Supplements (LNS) for Pregnant and Lactating Women and Their Infants N/A
Active, not recruiting NCT02441426 - Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development N/A
Recruiting NCT05119218 - Gut Microbiota Stunted Children NTT
Recruiting NCT03378141 - Maternal Nutrition Interventions in Uttar Pradesh, India N/A
Terminated NCT04233944 - Uganda Birth Cohort Study
Active, not recruiting NCT04565314 - ELICIT 2.0: Pilot Study of the Effect of Maternal Protein Supplementation During Lactation on Childhood Growth N/A
Completed NCT03299218 - Effectiveness of SNF, Cash and BCC to Prevent Stunting Among Children 6-24 Months in Rahim Yar Khan, Pakistan N/A
Completed NCT00508131 - Effectiveness of Iron-Fortified Milk on Iron Status and Anemia in Young Children in Mexico Phase 3
Completed NCT03346473 - The Double Burden of Malnutrition Among Adolescents in Low-income and Middle-income Countries N/A