Stress Urinary Incontinence Clinical Trial
Official title:
Changes in the Bladder Micro-environment Following Midurethral Sling Surgery for Stress Urinary Incontinence
This observational cohort study is aimed at determining changes in the cytokine expression profile as well as the urinary and vaginal microbiome of women undergoing midurethral sling placement for the treatment of stress urinary incontinence.
Primary Objectives:
This is a pilot study to evaluate how midurethral sling (MUS) placement for the treatment of
stress urinary incontinence (SUI) affects the bladder microenvironment, specifically the
local microbial community or "microbiome" of the bladder and the cytokine expression profile.
The investigators also aim to correlate any changes in the microbiome or cytokine expression
profile with patient-reported urinary symptoms preoperatively and postoperatively.
Specific Aim 1: Assess the change in the urinary and vaginal microbiome (preoperatively to
postoperatively) in women undergoing MUS placement for the treatment of SUI. The
investigators hypothesize that the bladder environment will be disturbed by surgery involving
the lower urinary tract and will show demonstrable changes in the urinary and vaginal
microbiota.
Specific Aim 2: Characterize the cytokine profile of the bladder (preoperatively to
postoperatively) in women undergoing MUS placement for the treatment of SUI. The
investigators hypothesize that MUS treatment will change the cytokine profile of the bladder
and lead to alterations in the expression of pro-inflammatory cytokines.
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