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NCT04544163 Clinical Trial

Magnesium Versus High Dose Fentanyl in Endotracheal Intubation

Stress Response Clinical Trial

Official title:
Magnesium Versus High Dose Fentanyl in Attenuating Stress Response to Endotracheal Intubation

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04544163
Other study ID # AP2007-50108
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date September 5, 2020
Est. completion date May 5, 2021

Study information
Verified date May 2021
Source National Cancer Institute, Egypt
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation

Description:

to assess the effect of MgSO4 combined with fentanyl compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation

Recruitment information / eligibility
Status Completed
Enrollment 160
Est. completion date May 5, 2021
Est. primary completion date May 2, 2021
Accepts healthy volunteers No
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation - ASA I II - 18 to 60 Exclusion Criteria: - allergy to any of the used drugs - renal or hepatic impairment - hypertensive patients, patients with cardiovascular or cerebrovascular diseases

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Magnesium sulfate- Fentanyl
drug administration before intubation
• Fentanyl 4Mcg/kg
drug administration with induction of anesthesia
• Fentanyl 2Mcg/kg
drug administration with induction of anesthesia
• Lidocaine 1.5 mg/kg
drug administaration 90 sec before intubation

Locations
Country Name City State
Egypt Walaa Y Elsabeeny Cairo

Sponsors (1)
Lead Sponsor Collaborator
National Cancer Institute, Egypt

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary heart rate values changes in heart rate values after intubation 5 minutes
Secondary blood pressure mean arterial blood pressure values 5 minutes
Secondary coughing during intubation coughing during intubation lntubation time
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