Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia

Stress Reaction Clinical Trial

Official title:

Effect of Tetanic Stimuli on Photoplethysmogram During General Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05899686
• Other study ID #: PT1502
• Status: Completed
• Phase: N/A
• Start date: January 27, 2016
• Est. completion date: May 12, 2016

Study information

• Verified date: May 2024
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

Description:

A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations (Ulnar nerve, Facial nerve, Posterior Tibial nerve) in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplethysmography.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: May 12, 2016
• Est. primary completion date: May 12, 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Surgical patients
• Undergoing general anesthesia
• Able to consent in english
• 18 years of age or older

Exclusion Criteria:

• Under 18 years of age
• unable to consent in english
• receiving regional anesthesia

Related Conditions & MeSH terms

• Fractures, Stress
• Stress Reaction

Intervention

Device:
• Tetanic Stimulus
5 second 100 Hz 70 mA tetanic stimulus will be applied to three different anatomical locations in each subject.

Locations

Country	Name	City	State
United States	University of California San Francisco	San Francisco	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, San Francisco

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Tetanic Stimulus Induced Change in Photoplethysmography Light Transmission (in Analog to Digital Units as Measured Using a Pulse Oximeter) From Pre Stimulus Baseline	Tetanic stimulation will induce peripheral vasoconstriction. This will be measured using photoplethysmography. During peripheral vasoconstriction the light transmission through finger will increase. The primary outcome will be the maximum change in light transmission (as measured by photoplethysmography) within 60 seconds after a tetanic stimulus as compared to pre stimulus baseline values. These maximal light transmission changes will be compared between the three different tetanic stimulus sites	Maximum light transmission change from pre tetanic stimulus baseline within 60 seconds after the tetanic stimulus