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Predictive Elements of Trauma and Its After-effects: Importance of the Quality of Neurobiological Response to Stress — LIFT-UP  

Stress Reaction Clinical Trial

Official title:
Predictive Elements of Trauma and Its After-effects: Importance of the Quality of Neurobiological Response to Stress

Clinical Trial Summary

The neurobiological response to stress is an adaptive response allowing us to cope with the multiple aggressions of daily life. This response orchestrates the body's systemic reaction. The intensity of response to stress can modify the body's functioning, which implies a variety of fields where biomarkers may be isolated: immunity, psychology, neurophysiology, integrative physiology. When stress is too intense or prolonged, response to stress may become misfitted and deleterious. This study is based on the hypothesis that a severe physical or psychological trauma is associated with an intense and misfitted stress that is responsible from an undue immuno-inflammatory activation (through sympathetic activation). The result is a subinvasive state of systemic and tissue inflammation (low-noise inflammation), responsible for the mid-term deleterious consequences of the traumatic event. The objective of this study is to understand how the dysregulation of intense stress simultaneously generates an initial pathological state and an alteration of mid-term evolution (which is considered as a poor prognosis and/or as responsible for after-effects). The investigators wish to identify relevant biomarkers of the mechanisms activated during intense stress and influencing the immuno-inflammatory and epigenetic spheres with deleterious consequences on physiological and psychological functions.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04530214
Study type Observational
Source Direction Centrale du Service de Santé des Armées
Contact Anaïs DUFFAUD
Phone 178651315
Email anais.duffaud@intradef.gouv.fr
Status Recruiting
Phase
Start date November 4, 2020
Completion date May 2023
View Details
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