Effect of Location of Tetanic Stimuli on Photoplethysmogram

Stress Reaction Clinical Trial

Official title:

Effect of Location of Tetanic Stimuli on Photopethysmogram During General Anesthesia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03648853
• Other study ID #: PT1801
• Status: Completed
• Phase: N/A
• Start date: September 1, 2018
• Est. completion date: November 30, 2018

Study information

• Verified date: May 2020
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The effect of the location of tetanic stimulus on photoplethysmography signals will be studies in patients under general anesthesia.

Description:

A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplythysmography.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: November 30, 2018
• Est. primary completion date: November 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Surgical patients general anesthesia able to consent in english

Exclusion Criteria:

• regional anesthesia unable to consent in english under 18 yrs of age

Related Conditions & MeSH terms

• Fractures, Stress
• Stress Reaction

Intervention

Device:
• Tetanic Stimulus
5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations in a random order

Locations

Country	Name	City	State
United States	University of California San Francisco	San Francisco	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, San Francisco

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Photoplethysmography (PPG)	Change in the PPG signal in response to tetanic stimulus. A tetanic stimulus will cause vasoconstriction which can be recorded as a decrease in PPG AC/DC. The outcome measure is the maximum decrease in AC/DC from baseline. Maximum decrease happens typically in 30-60 seconds after the stimulus. Thus, data was collected immediately before (baseline) and for 2 min after the stimulus. After the stimulus AC/DC values return to baseline in a few minutes. Baseline AC/DC measures a relative state of blood vessel tone. In anesthetized patients the AC/DC values can range from close to 0 to above 10. The higher the value, the more vasodilated the subject is.	1-2 minutes