Acute Plasma Abeta Responses to Stress

Status Recruiting

Clinical Trial Summary

Research has shown that activation of the sympathetic nervous system for extended periods or during certain times in life can increase the risk for Alzheimer's disease. Some research in animal models show that acute activation of the sympathetic nervous system through stress exposure can increase certain Alzheimer's disease-related biomarkers, such as amyloid-beta, within hours of exposure. However, how acute sympathetic nervous system activation via stress exposure affects amyloid-beta levels in humans has yet to be examined. In this study, the investigators will examine whether brief increases in sympathetic activation result in immediate changes in plasma amyloid-beta levels in the five hours after exposure.

Clinical Trial Description

Aim 1: determine whether acute exposure to stress (increasing sympathetic nervous system activation) increases plasma amyloid-beta-40 and amyloid-beta-42 in the five hours following exposure. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05521919
Study type	Interventional
Source	University of Southern California
Contact	Lab Manager
Phone	213-740-9543
Email	matherlab@usc.edu
Status	Recruiting
Phase	N/A
Start date	February 14, 2024
Completion date	December 2024

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