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Stress Disorders, Traumatic clinical trials

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NCT ID: NCT05281640 Completed - Schizophrenia Clinical Trials

Psychological Interventions for Complex PTSD And Schizophrenia-Spectrum Disorder: PICASSO Trial

PICASSO
Start date: February 28, 2022
Phase: N/A
Study type: Interventional

Psychosis is a highly distressing mental health condition, affecting up to 3% of the population. Conceptually, it has much in common with complex post-traumatic stress disorder (CPTSD), a recently introduced condition in ICD-11. Both involve negative self-esteem, impaired emotion regulation ability, interpersonal difficulties and intrusive trauma- related experiences (i.e. intrusive thoughts, flashbacks, nightmares). Both have been causally related to childhood trauma, such as abuse, neglect and loss. The current project will examine the feasibility of conducting an 'Umbrella trial' to test whether CPTSD is causally related to psychosis, and develop more effective trauma-focused psychological interventions for psychotic symptoms by treating underlying experiences of/reactions to trauma. An Umbrella trial involves running several individual randomised controlled trials concurrently. In this study, each trial will test whether psychological interventions designed to reduce different CPTSD symptoms cause improvements in psychotic symptoms. If the investigators can establish feasibility of this Umbrella trial, and if a definitive version shows that interventions for CPTSD also reduce psychosis, then this would be a breakthrough in both the conceptualisation and treatment of psychosis which will help transform the care of people with psychosis. Demonstrating the feasibility of our proposed methodology would also help to accelerate the development of interventions for other mental health problems.

NCT ID: NCT05261230 Completed - Clinical trials for Post Traumatic Stress Disorder

Vedic Counselling for Women Victims of Domestic Abuse

Start date: October 21, 2021
Phase: N/A
Study type: Interventional

The Vedic Counselling is the whole person approach, system of total life style counselling based on 'Vedic Laws of right living, right actions, right relationship and right awareness'.Vedic Counselling was developed as trauma focused therapy for this study to treat female victims of domestic abuse.

NCT ID: NCT05242263 Completed - PTSD Clinical Trials

ACT With Feedback for Post Traumatic Stress Disorder (PTSD)

Start date: August 12, 2019
Phase: N/A
Study type: Interventional

The purpose of this study is to explore the efficacy of Attention Control Training with the inclusion of feedback for Post Traumatic Stress Disorder (PTSD). It seems that the most efficient ABMT method to balance attention bias variability (ABV) among individuals with PTSD is Attention Control Training (ACT). This type of training is designed to balance attention allocation towards threat-related and neutral stimuli. A few studies have further shown that this training type succeeds in balancing the aberrant fluctuations in attention bias observed in patients with PTSD, and that this leads to a reduction in PTSD symptoms (Badura-Brack et al., 2015). The purpose of the current study is to examine the efficacy of ACT that also includes feedback. Specifically, we intend to test whether the inclusion of feedback on top of standard ACT may enhance training efficacy in reducing ABV and in reducing PTSD symptoms.

NCT ID: NCT05226481 Completed - PTSD Clinical Trials

Investigating the Effect of Evidence-based Treatment for Post-traumatic Stress Disorder Among Youth

Start date: January 1, 2018
Phase:
Study type: Observational

Trauma-focused cognitive-behavioral therapy (TF-CBT) is an evidence-based practice (EBP) for the treatment of posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) among children and adolescents. In the current study, data were collected from youth receiving TF-CBT in specialized child and adolescent mental health services (CAMHS) and their caregivers in 2018-2021.

NCT ID: NCT05212714 Completed - Clinical trials for Stress Disorders, Post-Traumatic

taVNS to Reduce PTSD Symptoms in WTC Responders

taVNS
Start date: March 31, 2022
Phase: N/A
Study type: Interventional

This study seeks to conduct a randomized, double-blind pilot study, to determine whether the Transcutaneous Auricular Vagus Nerve Stimulation and study procedure are feasible and acceptable for use with World Trade Center responders with Post Traumatic Stress Disorder.

NCT ID: NCT05207462 Completed - Clinical trials for Post Traumatic Stress Disorder

A Feasibility Study of Intensive Treatment With Prolonged Exposure

Start date: January 24, 2022
Phase: N/A
Study type: Interventional

The primary objective with this study is to investigate the feasibility and acceptability of intensive treatment with prolonged exposure (I-PE) in regular Swedish psychiatric care. The secondary objective is to investigate preliminary effects of i-PE in terms of reducing symptoms of post-traumatic stress, depression and increase quality of life.

NCT ID: NCT05207436 Completed - Clinical trials for Post Traumatic Stress Disorder

Brief Cognitive Behavioral Conjoint Therapy for PTSD With Adjunctive Intranasal Oxytocin

CBCT+OT
Start date: January 17, 2022
Phase: Phase 2
Study type: Interventional

In 2019 VA mandated that all Veterans seeking mental health care have access to flexible family mental health services in VA (VHA directive 1163.04). This study aims to respond to this mandate by further improving an evidence-based PTSD treatment designed to decrease PTSD symptoms and improve relationship satisfaction for Veterans and their romantic partners. Brief Cognitive-Behavioral Conjoint Therapy (B-CBCT), an 8-session dyadic psychotherapy for PTSD, has been found to significantly reduce PTSD symptoms, but the effects of B-CBCT on relationship satisfaction are less reliable and robust. Pharmacological augmentation of psychotherapy utilizing intranasal oxytocin, a neurohormone that influences mechanisms of trauma recovery and social behavior, may help improve relationship satisfaction outcomes. If successful, the proposed study will advance knowledge of strategies for improving Veterans' quality of life by improving their intimate relationships along with PTSD symptoms.

NCT ID: NCT05206734 Completed - Schizophrenia Clinical Trials

Risk of Mental Health Conditions in Children and Young Adults With Inflammatory Bowel Disease and Influence on Health

Start date: January 5, 2022
Phase:
Study type: Observational

This study is a large population-based analysis in the United Kingdom (UK) using routine primary care data to investigate the risk of mental health conditions in children, adolescents and young adults with Inflammatory Bowel Disease, compared to those without Inflammatory Bowel Disease. The study will also compare the impacts on quality-of-life outcomes and use of healthcare services between people with Inflammatory Bowel Disease with and without mental health conditions.

NCT ID: NCT05186844 Completed - Clinical trials for Posttraumatic Stress Disorder

Posttraumatic Stress Disorder in Parents and Children After Discharge From the Pediatric Intensive Care Unit

PTSD
Start date: January 1, 2019
Phase:
Study type: Observational [Patient Registry]

Background: If disorders that occur immediately after a trauma are not treated, they may become chronic and turn into severe health problems. Objectives: This study was conducted with children who had spent time in an intensive care unit and their parents to examine the development of posttraumatic stress disorder (PTSD) in both children and parents. Methods: The study was a cross-sectional study. A total of 110 children, 98 mothers and 80 fathers were included in the study.

NCT ID: NCT05178316 Completed - Clinical trials for Post Traumatic Stress Disorder

A Study of JZP150 in Adults With Posttraumatic Stress Disorder

Start date: December 29, 2021
Phase: Phase 2
Study type: Interventional

This is a 12-week, double-blind, placebo-controlled, randomized, parallel-group, multicenter study of the safety and efficacy of JZP150 in the treatment of adult participants with post-traumatic stress disorder (PTSD).