Clinical Trials Logo
  1. Home
  2. Stomatitis
  3. NCT03778008

Recombinant Bovine Basic Fibroblast Growth Factor for the Treatment of Radiation Induced Oral Mucositis

Stomatitis Clinical Trial

Official title:
Recombinant Bovine Basic Fibroblast Growth Factor for the Treatment of Radiation Induced Oral Mucositis：An Open, Randomized, Controlled, Prospective Study

Clinical Trial Summary

Radiation therapy is one of the treatments for Nasopharyngeal carcinoma . The most common side effects of post-radiation may be radiation-induced oral mucositis . When severe, oral mucositis increases the risk of infection and may affect clinical outcomes due to treatment interruption, dose reduction, and reduced treatment compliance. In China, a quadruple mixture of dexamethasone, gentamicin, vitamin B12, and lidocaine is commonly used in patients who begin to have radiation-induced oral mucositis . However, the incidence of radiation-induced oral mucositis remains high. Recombinant bovine basic fibroblast growth factor is a multifunctional cell growth factor that stimulates the growth of cells derived from mesoderm and neuroectodermal cells and thus has a wide range of biological activities. The drug has different degrees of promotion on the three stages of the wound repair process, namely the local inflammatory reaction stage, cell proliferation and differentiation, granulation tissue formation stage and tissue reconstruction stage. The purpose of this randomized controlled trial was to evaluate the efficacy of recombinant bovine basic fibroblast growth factor as an intervention in radiation-induced oral mucositis for the treatment of nasopharyngeal carcinoma , with a commonly used quadruple mixture (from dexamethasone, gentamicin , vitamin B12 and lidocaine composition) were compared.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03778008
Study type Interventional
Source Second Affiliated Hospital of Nanchang University
Contact long Huang, PhD
Phone 13699549060
Email ndefy13211@ncu.edu.cn
Status Not yet recruiting
Phase Phase 2
Start date December 21, 2018
Completion date December 20, 2019
View Details
See also
  Status Clinical Trial Phase
Completed NCT02229136 - Miracle Mouthwash Plus Hydrocortisone vs Prednisolone Mouth Rinse for Mouth Sores Caused by Everolimus Phase 2
Completed NCT02762019 - Laser for Oral Mucositis in Pediatric Onco-hematology Phase 3
Recruiting NCT02945878 - Predictive Factors of Acute Oral Mucositis Induced by Chemo-radiotherapy for Local Advanced Nasopharyngeal Carcinoma N/A
Recruiting NCT05878405 - Methylene Blue Mouthwash for the Treatment of Oral Mucositis Pain in Patients With Cancer Phase 3
Completed NCT00323518 - A Phase II Controlled Trial of Velafermin for Prevention of Oral Mucositis Phase 2
Terminated NCT02326675 - Cryotherapy in the Prevention of Chemotherapy-Induced Mucositis in Stem Cell Transplant N/A
Active, not recruiting NCT01099891 - The Clinical Study for Evaluation of Efficacy and Safety of EGF on Oral Mucositis in Radiation Therapy Patients Phase 3
Terminated NCT01092975 - Safety of Phenylephrine for Oral Mucositis Prevention Phase 1
Terminated NCT00031551 - Evaluation of Efficacy and Mechanisms of an Antiinflammatory Intervention for Chemotherapy Related Mucosal Injury Phase 2
Completed NCT00385515 - Efficacy of SNX-1012 in the Treatment of Oral Mucositis Phase 2
Completed NCT03200340 - EC-18 for Oral Mucositis in Patients With Concomitant Chemoirradiation Phase 2
Not yet recruiting NCT05323058 - The Use of Tulsi Extract for The Management of Oral Mucositis in Head & Neck Cancer Patients Undergoing Radiotherapy Phase 2
Completed NCT01837446 - Morphine Mouthwash for Management of Oral Mucositis in Patients With Head and Neck Cancer Phase 2/Phase 3
Completed NCT00104065 - Safety and Efficacy of CG53135-05 in the Prevention of Oral Mucositis in Patients Receiving Bone Marrow Transplant Phase 2
Completed NCT03469284 - MOM's PAIN (Methylene Blue for Oral Mucositis' PAIN) Phase 2
Terminated NCT00075023 - Effectiveness of Topical Thalidomide to Treat Chronic Graft-Versus-Host-Disease Related Stomatitis Phase 2
Not yet recruiting NCT05010928 - Using Tea-based Mouthwash Relieve Stomatitis and Oral Ulcers Phase 2
Completed NCT02407834 - Effectiveness of Hygiene Solutions on Denture Biofilm Phase 4
Active, not recruiting NCT00101582 - Palifermin for the Reduction of Oral Mucositis in Patients With Locally Advanced Head and Neck Cancer Phase 3
Recruiting NCT06071637 - Low Power Laser Therapy As Prevention Of Oral Mucositis And Oropharyngeal Pain In Patients Undergoing Allogenetic HSCT Phase 3