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Stomach Ulcer clinical trials

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NCT ID: NCT00633412 Completed - Clinical trials for NSAID Associated Gastric Ulcers

A Comparative Efficacy and Safety Study of Nexium Delayed-Release Capsules (40mg qd and 20mg qd) Versus Ranitidine 150mg Bid for the Healing of NSAID-Associated Gastric Ulcers When Daily NSAID Use is Continued in Subjects in the US Only

Start date: February 2001
Phase: Phase 3
Study type: Interventional

Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. This study looks at the treatment of these gastric ulcers with one of the three following treatment groups for up to 8 weeks: esomeprazole 40 mg once daily; esomeprazole 20 mg once daily; or ranitidine 150 mg twice daily for subjects in the US only.

NCT ID: NCT00629928 Completed - Clinical trials for NSAID Associated Gastric Ulcers

Ulcer Prevention II

Start date: February 2001
Phase: Phase 3
Study type: Interventional

Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. This study looks at the prevention of these gastric ulcers, in patients deemed to be at risk, with either esomeprazole 40 mg once daily; esomeprazole 20 mg once daily.

NCT ID: NCT00629512 Completed - Clinical trials for NSAID Associated Gastric Ulcers

Prevention of Gastric Ulcers

Start date: March 2001
Phase: Phase 3
Study type: Interventional

Nonsteroidal anti-inflammatory drugs (NSAIDS) are often associated with gastric ulcers. This study looks at the prevention of these gastric ulcers with one of the three following treatment groups for up to 8 weeks: esomeprazole 40 mg once daily; esomeprazole 20 mg once daily; versus placebo; in patients at risk.

NCT ID: NCT00595517 Completed - Clinical trials for Rheumatoid Arthritis

Long Term Study to Investigate the Efficacy & Safety of D961H (Esomeprazole) for the Prevention of NSAIDs-induced Ulcer

Start date: October 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the Safety and tolerability of D961H (Esomeprazole) 20 mg once daily for up to 52 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily nonsteroidal anti-inflammatory drug (NSAID) therapy by evaluating AE, clinical laboratory value and vital signs.

NCT ID: NCT00543868 Completed - Duodenal Ulcer Clinical Trials

MK0782 + Low-Dose Aspirin 7-Day Erosion Endoscopy Study (0782-001)

Start date: June 2004
Phase: Phase 2
Study type: Interventional

This study will determine how if MK0782 is safe and tolerable and to determine how often and the severity of stomach and small intestine ulcers develop following administration of MK0782 plus enteric coated aspirin, rofecoxib 25mg plus enteric coated aspirin, naproxen 500 mg puls enteric coated asprin vs placebo. This is an early phase trial and some specific protocol information is in progress and not publicly available at this time. (Full information is available to trial participants).

NCT ID: NCT00542789 Completed - Clinical trials for Rheumatoid Arthritis

Comparative Efficacy & Safety Study of Esomeprazole Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With NSAID

Start date: August 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess the efficacy of esomeprazole (D961H) 20 mg versus placebo once daily for up to 24 weeks of treatment involving patients with a history of gastric and/or duodenal ulcers receiving daily nonsteroidal anti-inflammatory drug (NSAID) therapy by evaluating presence or absence of gastric and/or duodenal ulcers throughout the treatment period (24 weeks) in terms of efficacy on prevention of gastric and/or duodenal ulcers

NCT ID: NCT00527904 Completed - Gastric Ulcer Clinical Trials

A 12-month, Phase 3, Open-label, Multi-center Study to Evaluate the Long-term Safety of PN400 (VIMOVO)

Start date: March 2007
Phase: Phase 3
Study type: Interventional

This study uses an open-label design and will be conducted in approximately 60 sites aiming to enroll a total number of 200 subjects to ensure that at least 100 subjects will have 12 months exposure to PN400 (VIMOVO).

NCT ID: NCT00527787 Completed - Gastric Ulcer Clinical Trials

Evaluating PN 400 (VIMOVO) in Reducing Gastric Ulcers Compared to Non-steroidal Antiinflammatory Drug (NSAID) Naproxen

Start date: September 2007
Phase: Phase 3
Study type: Interventional

This study uses a randomized, double-blind, controlled design to demonstrate that PN400 (esomeprazole and naproxen) is more effective in reducing the occurrence of gastroduodenal ulcers, dyspepsia, and heartburn in subjects at risk for developing NSAID-associated gastric ulcers compared to naproxen alone.

NCT ID: NCT00441727 Completed - Gastric Ulcer Clinical Trials

Study of Esomeprazole 20 mg or 40 mg vs Placebo Effectiveness on the Occurrence of Peptic Ulcers in Subjects on Low Dose Acetylsalicylic Acid (LDA)

Oberon
Start date: February 2007
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effect of esomeprazole 20 or 40 mg once daily versus placebo on the occurrence of peptic ulcers during 26 weeks in subjects on continuous low-dose acetylsalicylic acid.

NCT ID: NCT00428701 Completed - Gastric Ulcer Clinical Trials

An Open-label, Exploratory Trial to Assess Gastric Acid Control in Critically Ill Subjects Receiving Nexium

Start date: October 2006
Phase: Phase 4
Study type: Interventional

This study is being done to see if Nexium I.V. can reduce and control stomach acid in mechanically ventilated, critically ill patients in an Intensive Care Unit setting.