Association Between Mitochondrial DNA Content and Risk of Gastric Cancer

Stomach Neoplasms Clinical Trial

Official title:

Association Between Mitochondrial DNA Content and Risk of Gastric Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02944539
• Other study ID #: ZJ20161024
• Status: Completed
• Phase: N/A
• First received: October 24, 2016
• Last updated: October 24, 2016
• Start date: March 2016
• Est. completion date: September 2016

Study information

• Verified date: October 2016
• Source: Fourth Military Medical University
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Food and Drug Administratio
• Study type: Observational

Clinical Trial Summary

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of gastric cancer.The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for gastric cancer.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 600
• Est. completion date: September 2016
• Est. primary completion date: September 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

• 1.histological confirmed gastric adenocarcinoma; 2.receiving surgical resection; 3.no preoperative anticancer treatment; 4.alive at least 1 months after surgery.

Exclusion Criteria:

• 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Study Design

Observational Model: Case Control, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Stomach Neoplasms

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Fourth Military Medical University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Relative copy number of mitochondrial DNA	The ratio of mitochondrial DNA contents to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in patients suffered from gastric cancer when compared with control group.	From date of percutaneous coronary intervention until the date of discharging from hospital, assessed up to 5 days	No