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Vactosertib and Durvalumab in Gastric Cancer

Stomach Neoplasm Clinical Trial

Official title:
Vactosertib in Combination With Durvalumab (MEDI4736) in Patients With Gastric Cancer

Clinical Trial Summary

This trial will test the efficacy and safety of durvalumab in combination with vactosertib in patients with metastatic gastric cancers who failed ≥ 2 lines of chemotherapy

Clinical Trial Description

Efficacy and safety of durvalumab (anti-PD-L1) via IV infusion Q4W, in combination with vactosertib (TGF-beta inhibitor) PO bid for 5 days a week for up to a maximum of 12 months, will be tested in patients with metastatic hypermutated gastric cancers as ≥ 3rd-line setting until confirmed disease progression, unless there is unacceptable toxicity, withdrawal of consent, or another discontinuation criterion is met. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04893252
Study type Interventional
Source National Cancer Center, Korea
Contact Hark K Kim, MD,PhD
Phone +82-31-920-2238
Email hkim@ncc.re.kr
Status Recruiting
Phase Phase 2
Start date June 1, 2021
Completion date December 31, 2023
View Details
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