STEMI Clinical Trial
Official title:
NO Reflow Phenomenon and Comparison to the Normal Flow Population Post Primary Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction
Background No reflow phenomenon is described in up to 65% of patients undergoing primary
percutaneous coronary intervention for ST elevation myocardial infarction (STEMI). It is
known to be associated with worse outcomes but predictors of no reflow are not clearly
described.
Objectives A single centre case-control observational study of patients presenting with acute
myocardial infarction appropriate for PPCI comparing baseline clinical, biochemical and
angiographic characteristics between patients with no reflow phenomenon and those without.
Aiming to establish incidence for the UK population.
Secondary outcomes will be to gain further insight into those presenting with STEMI for PPCI
and develop a risk model to guide management and clinical outcomes of patients to 30days.
Methods This study will prospectively recruit all consecutive patients attending a single
centre for primary percutaneous coronary intervention for STEMI. Angiographic assessment of
the recanalised epicardial vessel will be used to diagnose no reflow (reduced TIMI flow or
blush grade). Baseline demographic, angiographic and biochemical characteristics and outcomes
at 30days for reflow and no reflow cohorts will be statistically assessed and compared with
logistic regression.
n/a
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