Weight Loss Clinical Trial
Official title:
Can Increased Dietary Protein Prevent the Suppression of Metabolism and Maintain Anabolic Sensitivity of Bone and Skeletal Muscle During Caloric Restriction?
The purpose of this study is to determine if an increased protein intake can attenuate the suppression of metabolic and anabolic hormones during caloric restriction
1. Preliminary testing
Prior to the study start, participants will be weighed and body composition will be
determined using calipermetry (7 sites) and bioelectrical impedance. Peak oxygen uptake
(VO2peak) will be assessed using an incremental exercise test on a bicycle ergometer.
2. Randomization
Participants will proceed through each of the following conditions lasting 5 days:
CR-LP: Participants will be restricted to 30 kcal/kg FFM/day and protein intake will be
low (0.8 g/kg BW/day).
CR-HP: Participants will be restricted to 30 kcal/kg FFM/day and protein intake will be
high (1.7 g/kg BW/day).
CON: Participants will be in energy balance and consume 1.7 g protein/kg BW/day.
3. Diet Prescription
Dietary energy intake will be controlled using clinical products and maltodextrin to
meet target energy intakes. Participants will received calcium and Vitamin D
supplementation throughout the study.
4. Exercise Prescription
During all conditions, participants will conduct daily supervised exercise on a bicycle
ergometer at an exercise intensity of 60% VO2peak. Exercise duration will be adjusted
individually such that exercise energy expenditure will amount to 15 kcal/kg FFM/day.
Additional exercise and intense physical activity will be prohibited.
5. Assessments
The following assessments will be conducted prior to the start of each condition as well
as upon completion of each condition: body weight and composition (impedance), fasting
blood draw for assessment of metabolic and anabolic hormones, resting metabolic rate,
aerobic fitness (VO2peak), and questionnaires.
6. Washout
Once a participant has completed a study condition, participant will be allowed a washout of
at least 14 days to allow protein balance to return to baseline (Hoffer & Forse, 1990).
During this time, participants will resume their regular diet and physical activity.
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