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Stage IV Small Cell Lung Cancer clinical trials

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NCT ID: NCT01859741 Terminated - Clinical trials for Stage IV Small Cell Lung Cancer

A Phase 1b/2 Study of OMP-59R5 (Tarextumab) in Combination With Etoposide and Platinum Therapy

PINNACLE
Start date: January 7, 2012
Phase: Phase 1/Phase 2
Study type: Interventional

The study consists of a Phase1b lead-in portion to determine the maximum tolerated dose (MTD) of OMP-59R5 (tarextumab) in combination with etoposide (EP) for 6 cycles followed a Phase 2, multi center, randomized, placebo-controlled portion comparing the efficacy and safety of OMP-59R5 in combination with EP for 6 cycles followed by single agent OMP-59R5 relative to EP alone for 6 cycles in subjects receiving first-line therapy for extensive stage small cell lung cancer.