Stage IV Colorectal Cancer Clinical Trial
Official title:
Feasibility of a 6-Week Aerobic Exercise Program During Chemotherapy for Metastatic Colorectal Cancer
Verified date | August 2018 |
Source | University of Southern California |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This pilot clinical trial studies how well aerobic exercise works in improving quality of life and health-related outcomes in patients with stage IV colorectal cancer undergoing chemotherapy. Aerobic exercise during chemotherapy may improve quality of life and reduce fatigue and inflammation in the blood related to heart disease and diabetes in patients with stage IV colorectal cancer.
Status | Terminated |
Enrollment | 2 |
Est. completion date | July 5, 2018 |
Est. primary completion date | July 5, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Newly diagnosed metastatic (stage IV) colorectal cancer - Undergoing chemotherapy (have had 1 or 2 chemotherapy cycles infused at time of data collection; this will allow for any systemic inflammatory changes due to chemotherapy to set in); only patients with 1st or 2nd line therapy will be included - Able to initiate a supervised exercise program (free from any CV, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity) - Free from uncontrolled chronic disease including diabetes, hypertension, or thyroid disease - Currently participate in less than 60 minutes of physical activity/week - Willing to travel to the exercise facility at University of Southern California (USC) (parking fees and public transportation permits will be provided) - Speak English or Spanish Exclusion Criteria: - Uncontrolled hypertension or other uncontrolled chronic disease (e.g. diabetes mellitus, thyroid disease, pulmonary disease, etc) - Moderate to highly active level of physical activity (e.g. currently participating in > 60 minutes of moderate aerobic activity weekly) - Orthopedic or other restrictions or contraindications to exercise - Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements - Patients must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants |
Country | Name | City | State |
---|---|---|---|
United States | Los Angeles County-USC Medical Center | Los Angeles | California |
United States | USC / Norris Comprehensive Cancer Center | Los Angeles | California |
Lead Sponsor | Collaborator |
---|---|
University of Southern California | National Cancer Institute (NCI) |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | Change in arterial stiffness/geometry | Assessed by ultrasound | Baseline up to 31 weeks | |
Other | Change in endothelial function | Assessed by flow-mediated dilation | Baseline up to 31 weeks | |
Primary | Total number of minutes exercised per week with >80% total weekly minutes (48/60 minutes) completed | The study will assess the feasibility using average weekly minutes of exercise completion (minutes/week) of all participants. Feasibility will be determined based on the total number of minutes exercised per week with >80% total weekly minutes (48/60 minutes) completed deeming this trial as feasible. | Up to 6 weeks | |
Secondary | Change in biomarkers of systemic inflammation | Change in biomarkers will be examined by a paired sample t-test, with a level of significance set at p <0.05. | Baseline up to 31 weeks | |
Secondary | Change in cancer-related fatigue | Assessed by the National Institutes of Health (NIH) Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue Scale | Baseline up to 31 weeks | |
Secondary | Change in QOL | Assessed by the Functional Assessment of Cancer Therapy-Colorectal cancer (FACT-C) | Baseline up to 31 weeks |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT01704703 -
Study of FOLFIRI + Panitumumab Using Ultra-selection Technology of Patients With Stage IV Colorectal Cancer Refractory to Irinotecan Without Any Mutation on KRAS, PIK3Ca, BRAF and NRAS Genes Detected With Highly Sensitive Techniques
|
Phase 2 | |
Terminated |
NCT02960282 -
Gut Microbiome in Fecal Samples From Patients With Metastatic Cancer Undergoing Chemotherapy or Immunotherapy
|
||
Completed |
NCT01998152 -
Individualized Nutritional Counselling During Chemotherapy for Colorectal Cancer (COLONUT)
|
N/A | |
Not yet recruiting |
NCT06287723 -
French Assessment of MRD by Liquid Biopsies in Colorectal With Liver Metastasis Patients (FRENCH.MRD.CRLM)
|
||
Completed |
NCT03005002 -
Durvalumab and Tremelimumab in Treating Patients With Microsatellite Stable Metastatic Colorectal Cancer to the Liver
|
Phase 1 | |
Completed |
NCT03095781 -
Pembrolizumab and XL888 in Patients With Advanced Gastrointestinal Cancer
|
Phase 1 | |
Active, not recruiting |
NCT04267575 -
Canady Helios Cold Plasma Scalpel Treatment at the Surgical Margin and Macroscopic Tumor Sites
|
N/A | |
Recruiting |
NCT03368963 -
TAS102 in Combination With NAL-IRI in Advanced GI Cancers
|
Phase 1/Phase 2 | |
Active, not recruiting |
NCT04670445 -
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
|
N/A | |
Active, not recruiting |
NCT01271582 -
Investigation of Association Between UGT1A1 Polymorphisms and Irinotecan Toxicity in Korean Patients
|
Phase 4 | |
Active, not recruiting |
NCT03800602 -
Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer
|
Phase 2 | |
Recruiting |
NCT05631574 -
Study of Covalent Menin Inhibitor BMF-219 in Adult Patients With KRAS Driven Non-Small Cell Lung Cancer, Pancreatic Cancer, and Colorectal Cancer
|
Phase 1 | |
Completed |
NCT03112668 -
Acceptance and Commitment Therapy in Improving Well-Being in Patients With Stage III-IV Cancer and Their Partners
|
N/A | |
Terminated |
NCT01550510 -
Research Study of IV Vitamin C in Combination With Irinotecan vs Irinotecan Alone for Advanced Colorectal CA
|
Phase 1/Phase 2 | |
Recruiting |
NCT02919644 -
Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumour Homogenate After Curative Resection for Stage IV Colorectal Cancer.
|
Phase 2 | |
Completed |
NCT03373188 -
VX15/2503 and Immunotherapy in Resectable Pancreatic and Colorectal Cancer
|
Phase 1 | |
Terminated |
NCT04044430 -
Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer
|
Phase 1 | |
Completed |
NCT05025748 -
Ask Questions (ASQ):Implementation of a Communication Intervention
|
N/A | |
Completed |
NCT01722903 -
Detection of CTCs in Patients Undergoing Surgery for Stage IV Colorectal Cancer
|
N/A | |
Completed |
NCT02809716 -
High Definition Single Cell Analysis in Colorectal Cancer
|